136765-45-2 Usage
Description
Nitrazepam-D5, also known as the labeled analogue of Nitrazepam, is a benzodiazepine compound that serves as an internal standard for the quantification of nitrazepam by GCor LC-MS. It is a controlled substance with depressant properties, acting as an agonist at the GABAA receptor to produce anxiolytic and hypnotic effects. Nitrazepam-D5 is characterized by its yellow solid appearance and is primarily intended for forensic and research applications.
Uses
Used in Forensic Applications:
Nitrazepam-D5 is used as an internal standard for the quantification of nitrazepam in forensic investigations. It aids in the accurate measurement and analysis of nitrazepam levels in biological samples, such as blood or urine, to determine the presence and concentration of the drug in cases of drug-related crimes or accidents.
Used in Research Applications:
In the field of research, Nitrazepam-D5 is employed as an internal standard for the quantification of nitrazepam in various experimental setups. It helps researchers to study the pharmacological effects, interactions, and metabolism of nitrazepam, as well as to develop new drugs or therapies based on its properties.
Used in Drug Development:
Nitrazepam-D5 can be utilized in the development of new drugs with similar or improved properties to nitrazepam. By using it as an internal standard, researchers can better understand the pharmacokinetics, pharmacodynamics, and potential side effects of new compounds, leading to the development of safer and more effective medications.
Used in Quality Control:
Pharmaceutical companies may use Nitrazepam-D5 as an internal standard to ensure the quality and consistency of nitrazepam-containing products. By incorporating it into their quality control processes, they can accurately measure the concentration of nitrazepam in their products and ensure that they meet the required standards for safety and efficacy.
Used in Toxicology Studies:
Nitrazepam-D5 can be employed in toxicology studies to investigate the potential toxic effects of nitrazepam and its metabolites. By using it as an internal standard, researchers can accurately measure the levels of nitrazepam and its metabolites in biological samples, helping to determine the toxicological profile of the drug and identify potential risks associated with its use.
Check Digit Verification of cas no
The CAS Registry Mumber 136765-45-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,6,7,6 and 5 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 136765-45:
(8*1)+(7*3)+(6*6)+(5*7)+(4*6)+(3*5)+(2*4)+(1*5)=152
152 % 10 = 2
So 136765-45-2 is a valid CAS Registry Number.
136765-45-2Relevant articles and documents
Preparation method of stable isotope labeled nitrazepam internal standard reagent
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, (2021/10/16)
The invention relates to a preparation method of a stable isotope labeled nitrazepam internal standard reagent for food safety detection, and belongs to the field of research and development of standard substances for food safety detection. The stable isotope labeled nitrazepam is obtained from stable isotope labeled phenylboronic acid as a raw material through catalytic addition, acylation, cyclization and final separation and purification. The process has the advantages that the raw material required for synthesis is simple and easy to obtain, the operation is simple, the reaction conditions are mild, the final product is high in chemical purity, isotope abundance is not diluted, toxic and carcinogenic chemical reagents are not used, and the risk of personnel health and environmental pollution is effectively reduced. The chemical purity of the stable isotope labeled nitrazepam prepared by the preparation method can reach 98% or above, the isotope abundance can reach 98% or above, and the technical requirements of a stable isotope labeled internal standard reagent required by a liquid chromatography-tandem mass spectrometry method for food safety detection can be met.
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