1367928-40-2Relevant articles and documents
Design and evaluation of 3-(benzylthio)benzamide derivatives as potent and selective SIRT2 inhibitors
Khanfar, Mohammad A.,Quinti, Luisa,Wang, Hua,Nobles, Johnathan,Kazantsev, Aleksey G.,Silverman, Richard B.
, p. 607 - 611 (2015)
Inhibitors of sirtuin-2 (SIRT2) deacetylase have been shown to be protective in various models of Huntington's disease (HD) by decreasing polyglutamine aggregation, a hallmark of HD pathology. The present study was directed at optimizing the potency of SI