136801-74-6

Basic information

• Product Name: 4H-1,3-Dioxin-4-one, 2,2-dimethyl-6-(2-oxo-2-phenylethyl)-
• CAS NO: 136801-74-6
• Molecular Formula: C14H14O4
• Molecular Weight: 246.263
• Mol File: 136801-74-6.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 4H-1,3-Dioxin-4-one, 2,2-dimethyl-6-(2-oxo-2-phenylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-1,3-Dioxin-4-one, 2,2-dimethyl-6-(2-oxo-2-phenylethyl)-(136801-74-6)
• EPA Substance Registry System: 4H-1,3-Dioxin-4-one, 2,2-dimethyl-6-(2-oxo-2-phenylethyl)-(136801-74-6)

Safety Data

• Hazardous Substances Data: 136801-74-6(Hazardous Substances Data)

Upstream product

• 65-85-0 benzoic acid 
• 1304104-42-4 C₉H₁₆O₄Si 
• 100-52-7 benzaldehyde 
• 130573-43-2 (2,2-dimethyl-6-methylene-6H-1,3-dioxin-4-yloxy)trimethylsilane 
• 4231-62-3 1-benzoyl-1H-benzotriazole 
• 5394-63-8 2,2,6-trimethyl-4H-1,3-dioxin-4-one 
• 136801-83-7 6-(2-hydroxy-2-phenylethyl)-2,2-dimethyl-4H-1,3-dioxin-4-one 
• 98-88-4 benzoyl chloride 

Downstream Products

• 1293991-75-9 3-[(1Z)-1-hydroxy-3-oxo-3-phenylprop-1-en-1-yl]-6,6,9a-trimethyl-5,6-dihydro-2H-furo[3,2-g]isochromene-2,9(9aH)-dione 
• 92687-12-2 6-(phenyl)-dihydro-2H-pyran-2,4(3H)-dione 
• 10225-39-5 2-butyl-1-phenyl-1,3-butanedione 
• 56745-75-6 2-pentyl-1-phenyl-1,3-butanedione 
• 857248-99-8 6-(1-benzoylpropyl)-2,2-dimethyl-4H-1,3-dioxin-4-one 
• 857249-03-7 6-(1-benzoylhexyl)-2,2-dimethyl-4H-1,3-dioxin-4-one 
• 857249-01-5 6-(1-benzoylpentyl)-2,2-dimethyl-4H-1,3-dioxin-4-one 
• 136801-83-7 6-(2-hydroxy-2-phenylethyl)-2,2-dimethyl-4H-1,3-dioxin-4-one 
• 5526-38-5 4-hydroxy-6-phenyl-2H-pyran-2-one 

Relevant articles and documents

A Biocatalytic Route to Highly Enantioenriched β-Hydroxydioxinones

A novel biocatalytic system to access a wide variety of β-hydroxydioxinones from β-ketodioxinones employing commercial engineered ketoreductases has been developed. This practical system provides a remarkably straightforward solution to limitations in acc

Versatile synthesis of acylfuranones by reaction of acylketenes with α-hydroxy ketones: Application to the one-step multicomponent synthesis of cadiolide B and its analogues

Functionalized acylfuranones have been prepared in a one-step procedure by thermal fragmentation of the corresponding dioxinones in the presence of hydroxy ketones in basic conditions. Multicomponent reactions also occur on addition of an aldehyde as a third reaction partner resulting in an expeditious access to cadiolide B and its analogues. A new method for the synthesis of acylfuranones is described based on the fragmentation of dioxinones to acylketenes followed by trapping with hydroxy ketones. Addition of an aldehyde as a third reaction partner leads to a supplementary aldolization/crotonization sequence resulting in an expeditious synthesis of cadiolide B and its analogues. Copyright

Antitumor agents 287. Substituted 4-amino-2H-pyran-2-one (APO) analogs reveal a new scaffold from neo-tanshinlactone with in vitro anticancer activity

4-Amino-2H-benzo[h]chromen-2-one (ABO) and 4-amino-7,8,9,10-tetrahydro-2H- benzo[h]chromen-2-one (ATBO) analogs were found to be significant in vitro anticancer agents in our previous research. Our continuing study has now discovered a new simplified (monocyclic rather than tricyclic) class of cytotoxic agents, 4-amino-2H-pyran-2-one (APO) analogs. By incorporating various substituents on the pyranone ring, we have established preliminary structure-activity relationships (SAR). Analogs 19, 20, 23, and 26-30 displayed significant tumor cell growth inhibitory activity in vitro. The most active compound 27 exhibited ED50 values of 0.059-0.090 μM.