136814-99-8

Basic information

• Product Name: N-ACETYL-2-(4-FLUORO-PHENYL)-D-GLYCINE
• Synonyms: N-ACETYL-2-(4-FLUORO-PHENYL)-D-GLYCINE ;(R)-Acetylamino-(4-fluoro-phenyl)-acetic acid;(R)-2-acetaMido-2-(4-fluorophenyl)acetic acid;N-Ac-R-4-Fluorophenylglycine
• CAS NO: 136814-99-8
• Molecular Formula: C₁₀H₁₀FNO₃
• Molecular Weight: 211.1897032
• Mol File: 136814-99-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 439.2°C at 760 mmHg
• Flash Point: 219.4°C
• Appearance: /
• Density: 1.313g/cm³
• Vapor Pressure: 1.72E-08mmHg at 25°C
• Refractive Index: 1.537
• PKA: 3.14±0.10(Predicted)
• CAS DataBase Reference: N-ACETYL-2-(4-FLUORO-PHENYL)-D-GLYCINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-ACETYL-2-(4-FLUORO-PHENYL)-D-GLYCINE(136814-99-8)
• EPA Substance Registry System: N-ACETYL-2-(4-FLUORO-PHENYL)-D-GLYCINE(136814-99-8)

Safety Data

• Hazardous Substances Data: 136814-99-8(Hazardous Substances Data)

Usage

General Description

N-ACETYL-2-(4-FLUORO-PHENYL)-D-GLYCINE is a chemical compound that consists of an acetyl group, a phenyl group substituted with a fluorine atom, and a glycine molecule. It is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. N-ACETYL-2-(4-FLUORO-PHENYL)-D-GLYCINE has potential therapeutic applications due to its ability to modulate biological targets and biochemical pathways. It is known for its anti-inflammatory and analgesic properties, making it a valuable ingredient in the development of new drugs for pain management and treatment of inflammatory disorders. Additionally, N-ACETYL-2-(4-FLUORO-PHENYL)-D-GLYCINE has potential applications in the field of medicinal chemistry and drug discovery, as it can serve as a building block for the development of novel drug candidates with improved therapeutic properties.

InChI:InChI=1/C10H10FNO3/c1-6(13)12-9(10(14)15)7-2-4-8(11)5-3-7/h2-5,9H,1H3,(H,12,13)(H,14,15)/t9-/m1/s1

Upstream product

• 7292-73-1 (2RS)-N-(p-fluorophenyl)glycine 
• 56464-70-1 2-amino-2-(4-fluorophenyl)acetonitrile 
• 459-57-4 4-fluorobenzaldehyde 
• 797039-94-2 N-(cyano(4-fluorophenyl)methyl)acetamide 
• 60-35-5 acetamide 
• 201230-82-2 carbon monoxide 
• 153381-37-4 N-acetyl-4-fluorophenylglycine 

Relevant articles and documents

Chemoenzymatic approaches to the dynamic kinetic asymmetric synthesis of aromatic amino acids

Enzymatic approaches for the production of amino acids by nitrilases are described. Dynamic kinetic asymmetric synthesis conditions were established for the aromatic aminonitriles, phenylglycinonitrile and 4- fluorophenylglycinonitrile, at high pH to produce the corresponding amino acid products in high enantiomeric excess. N-Acylation of aromatic aminonitriles led to spontaneous racemization at pH 8, allowing preferential enzymatic hydrolysis of the (R)-enantiomer to afford the product N-acylamino acids in up to 99% enantiomeric excess (ee).

HOMOCHIRAL HETEROORGANIC ANALOGS OF NATURAL COMPOUNDS. I. PREPARATIVE BIOCATALYTIC METHOD OF OBTAINING FLUORINE-CONTAINING L- AND D-PHENYLGLYCINES

A biocatalytic method of obtaining homochiral o- and p-fluorine-substituted phenylglycines by enantiomeric hydrolysis from N-phenylacetyl or N-acetyl derivatives under the action of Escherichia coli penicillin acylase or Streptoverticillium olivoreticuli aminoacylase is proposed.The L form of the amino acid and the unhydrolyzed D-enantiomer of the initial derivative are separated by extraction and chromatographic methods.The acid hydrolysis of the D-enantiomers of N-phenylacetyl derivatives of fluorine-substituted phenylglycines leads to partial (about 15percent) racemization.With a substantially higher (by two orders of magnitude) concentration of enzyme and an increase in the reaction time it is possible to use penicillinase as a catalyst for the hydrolysis of the D-enantiomer of the N-phenylacetyl derivative not accompanied by any appreciable racemization whatever.