136818-14-9

Basic information

• Product Name: 1-((1,1-DIMETHYLETHOXY)CARBONYL)-4-(3-((1-METHYLETHYL)AMINO)-2-PYRIDYL)PIPERAZINE
• Synonyms: 1-((1,1-DIMETHYLETHOXY)CARBONYL)-4-(3-((1-METHYLETHYL)AMINO)-2-PYRIDYL)PIPERAZINE
• CAS NO: 136818-14-9
• Molecular Formula: C₁₇H₂₈N₄O₂
• Molecular Weight: 320.42982
• Mol File: 136818-14-9.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-((1,1-DIMETHYLETHOXY)CARBONYL)-4-(3-((1-METHYLETHYL)AMINO)-2-PYRIDYL)PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-((1,1-DIMETHYLETHOXY)CARBONYL)-4-(3-((1-METHYLETHYL)AMINO)-2-PYRIDYL)PIPERAZINE(136818-14-9)
• EPA Substance Registry System: 1-((1,1-DIMETHYLETHOXY)CARBONYL)-4-(3-((1-METHYLETHYL)AMINO)-2-PYRIDYL)PIPERAZINE(136818-14-9)

Safety Data

• Hazardous Substances Data: 136818-14-9(Hazardous Substances Data)

Usage

General Description

The chemical 1-((1,1-Dimethylethoxy)carbonyl)-4-(3-((1-methylethyl)amino)-2-pyridyl)piperazine is a compound with a complex molecular structure. It contains a piperazine ring with a substituent of 1-(1,1-Dimethylethoxy)carbonyl at the 1-position and a 3-((1-methylethyl)amino)-2-pyridyl group at the 4-position. 1-((1,1-DIMETHYLETHOXY)CARBONYL)-4-(3-((1-METHYLETHYL)AMINO)-2-PYRIDYL)PIPERAZINE may have potential pharmaceutical or biochemical applications, given its structural features and functional groups. Its specific uses and properties would need to be further investigated and determined through scientific research and experimentation.

Upstream product

• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 153473-24-6 1-tert-butoxycarbonyl-4-(3-nitro-2-pyridyl)piperazine 
• 87394-48-7 1-(3-nitro-2-pyridinyl)piperazine 
• 5470-18-8 2-Chloro-3-nitropyridine 
• 111669-25-1 1-[1,1-dimethylethoxycarbonyl]-4-[3-amino-2-pyridinyl]piperazine 
• 67-64-1 acetone 

Downstream Products

• 403502-40-9 [5-(3-amino-phenyl)-1H-pyrrol-2-yl]-[4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-methanone 
• 403502-39-6 [5-(4-amino-phenyl)-1H-pyrrol-2-yl]-[4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-methanone 
• 403502-47-6 [5-(3-amino-phenyl)-1H-pyrrol-3-yl]-[4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-methanone 
• 403502-48-7 [5-(2-amino-phenyl)-1H-pyrrol-3-yl]-[4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-methanone 
• 403502-20-5 [4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-[5-(2-nitro-phenyl)-1H-pyrrol-2-yl]-methanone 
• 403502-41-0 [5-(2-amino-phenyl)-1H-pyrrol-2-yl]-[4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-methanone 
• 403502-46-5 [5-(4-amino-phenyl)-1H-pyrrol-3-yl]-[4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-methanone 
• 403502-19-2 [4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-[5-(3-nitro-phenyl)-1H-pyrrol-2-yl]-methanone 
• 403502-17-0 [4-[3-(isopropylamino)-2-pyridyl]piperazino]-[5-(4-nitrophenyl)-1H-2-pyrrolyl]methanone 
• 403502-23-8 [2-chloro-5-(2-nitro-phenyl)-1H-pyrrol-3-yl]-[4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-methanone 
• 136817-55-5 delavirdine 
• 1316754-35-4 2-(4-((1-benzyl-2-[⁽¹⁴⁾C]-imidazol-5-yl)methyl)piperazin-1-yl)-N-isopropylpyridin-3-amine 
• 1316754-32-1 2-(4-((1-benzyl-2-(methylthio)-2-[⁽¹⁴⁾C]-imidazol-5-yl)methyl)-piperazin-1-yl)-N-isopropylpyridin-3-amine 
• 1316754-33-2 1-(1-benzyl-2-[⁽¹⁴⁾C]-5-imidazoyl)-4-[3-(isopropylamino)-2-pyridyl]piperazine 

Relevant articles and documents

Method for preparing 1-t-butyloxycarboryl-4-[3-(alkylamino)-2-pyridyl]piperazine

A method for preparing 1-t-butyloxycarboryl-4-[3-(alkylamino)-2-pyridyl]piperazine belongs to the technical field of organic chemical preparation. The method comprises the following steps: mixing 1-t-butyloxycarboryl-4-(3-nitro-2-pyridyl)piperazine, a catalyst, a cocatalyst and an alkyl ketone, and adding the obtained mixture into an autoclave; sequentially replacing air in the autoclave with nitrogen and hydrogen, continuously introducing hydrogen, and carrying out a reaction; and cooling the reaction system to room temperature, filtering the obtained solution, separating out the obtained lower aqueous layer, drying the obtained upper organic layer, filtering the dried upper organic layer to remove a drying agent, carrying out distillation concentrating, and recrystallizing the obtained concentrate to obtain the target product. The 1-t-butyloxycarboryl-4-(3-nitro-2-pyridyl)piperazine used as a starting material undergoes a reductive alkylation reaction in the presence of the alkyl ketone, the catalyst and hydrogen in the same reactor to obtain the 1-t-butyloxycarboryl-4-[3-(alkylamino)-2-pyridyl]piperazine. The method has the characteristics of simplicity in operation, and high yield.

Strategy for 14C-labeling of a series of bis(heteroaryl) piperazines

Four bis(heteroaryl)piperazines labeled with carbon-14 in the 2-position of imidazole moiety were prepared as part of a 4-step (or 5-step) sequence from 5-hydroxymethyl-2-mercapto-1-benzylimida-zole-[2-14C] as a key synthetic intermediate which

Substituted indoles as anti-AIDS pharmaceuticals

Substituted indoles of formula (I) STR1 are useful anti-AIDS pharmaceuticals.