13682-32-1

Basic information

• Product Name: 5-methyl-2-phenyl-1H-imidazole-4-methanol
• Synonyms: 5-methyl-2-phenyl-1H-imidazole-4-methanol;2-Phenyl-4-methyl-5-hydroxymethylimidazole;4-Hydroxymethyl-5-methyl-2-phenylimidazole;(4-METHYL-2-PHENYL-1H-IMIDAZOL-5-YL)METHANOL;1H-Imidazole-4-methanol, 5-methyl-2-phenyl-;Einecs 237-187-5;2-Phenyl-4-hydroxyMethyl-5-MethyliMidazole;(5-Methyl-2-phenyl-1H-iMidazol-4-yl)Methanol
• CAS NO: 13682-32-1
• Molecular Formula: C₁₁H₁₂N₂O
• Molecular Weight: 188.22578
• EINECS: 237-187-5
• Mol File: 13682-32-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 446.1 °C at 760 mmHg
• Flash Point: 223.6 °C
• Appearance: /
• Density: 1.203 g/cm³
• Vapor Pressure: 9.65E-09mmHg at 25°C
• Refractive Index: 1.616
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-methyl-2-phenyl-1H-imidazole-4-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methyl-2-phenyl-1H-imidazole-4-methanol(13682-32-1)
• EPA Substance Registry System: 5-methyl-2-phenyl-1H-imidazole-4-methanol(13682-32-1)

Safety Data

• Hazardous Substances Data: 13682-32-1(Hazardous Substances Data)

Usage

General Description

5-methyl-2-phenyl-1H-imidazole-4-methanol, also known as MICONAZOLE, is an antifungal medication used to treat various fungal infections. It works by preventing the growth of fungi and yeast. Miconazole is often applied topically as a cream or powder, and can also be found in oral and intravaginal formulations. It is effective against a wide range of fungi, including those causing athlete's foot, ringworm, and yeast infections. Miconazole is generally well tolerated and has a low risk of side effects, making it a popular choice for treating fungal infections.

InChI:InChI=1/C11H12N2O/c1-8-10(7-14)13-11(12-8)9-5-3-2-4-6-9/h2-6,14H,7H2,1H3,(H,12,13)

Upstream product

• 77335-93-4 ethyl 4-methyl-2-phenyl-1H-imidazole-5-carboxylate 
• 1670-14-0 benzamidine monohydrochloride 
• 431-03-8 dimethylglyoxal 
• 68282-50-8 5-Methyl-2-phenyl-4-imidazolecarboxaldehyde 

Downstream Products

• 68283-02-3 8-methyl-6-phenyl-3H-imidazo[1,5-d][1,2,4]triazin-4-one 
• 69784-47-0 4-benzoyloxy-8-methyl-6-phenyl-imidazo[1,5-d][1,2,4]triazine 
• 69784-46-9 4-butyryloxy-8-methyl-6-phenyl-imidazo[1,5-d][1,2,4]triazine 
• 69784-45-8 4-acetoxy-8-methyl-6-phenyl-imidazo[1,5-d][1,2,4]triazine 
• 195606-24-7 5-(2-Phenyl-5-methyl-3H-imidazol-4-ylmethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 68282-50-8 5-Methyl-2-phenyl-3H-imidazole-4-carbaldehyde 

Relevant articles and documents

Synthesis and pharmacological evaluation of a novel series of 3-aryl-2-(2-substituted-4-methylthiazole-5-yl)thiazolidin-4-one as possible anti-inflammatory and antimicrobial agents

A new series of 3-aryl-2-(2-aryl/benzyl-4-methylthiazole-5-yl)thiazolidin- 4-one was synthesized by condensation of 2-aryl/benzyl-4-methylthiazole-5- carbaldehyde, aromatic amines and thioglycolic acid in toluene. All the synthesized compounds are characterized by IR, NMR and elemental or mass analysis. Sixteen out of the newly synthesized compounds were screened for in vivo anti-inflammatory activity using carrageenan-induced rat paw edema method. Some of the synthesized compounds exhibited good anti-inflammatory activity compared with indomethacin. The synthesized compounds were also evaluated for their in vitro antimicrobial activity. Some of the compounds showed mild antibacterial activity while most of the compounds showed good antifungal activity.

New synthetic routes to pyrrolo-[1,2-a]- and -[1,2-c]-imidazol-5-ones by flash vacuum pyrolysis

1-Substituted and 1,3-disubstituted pyrrolo[1,2-c]imidazol-5-ones 25-27 have been made in fair to excellent yield by flash vacuum pyrolysis (FVP) of the Meldrum's acid precursors 11-13. FVP of the appropriate propenoate precursor 23, 22 and 18-20 gives pyrrolo[1,2-c]imidazol-5-one 2, pyrrolo[1,2-a]-imidazol-5-one 3 and their 6-methyl derivatives 28-30 respectively in 32-90% yield. The mechanism of the propenoate pyrolyses involves rate determining E to Z isomerisation of the alkene followed by elimination of an alcohol and electrocyclisation to the fused ring products.

Substituted imidazo (1,5-D)-as-triazin-4-ols, and herbicidal use thereof

There are provided substituted imidazo[1,5-d]-as-triazin-4-ols, useful as herbicides for the pre- and postemergence control of undesired mono- and dicotyledonous plants.