136888-12-5

Basic information

• Product Name: 6-Chloro-4-aza-2-oxindoie
• Synonyms: 6-Chloro-4-aza-2-oxindoie;6-Chloro-4-aza-2-oxindole;6-Chloro-1H-pyrrolo[3,2-b]pyridin-2(3H)-one;6-Chloro-1,3-dihydropyrrolo[3,2-b]pyridin-2-one;2H-Pyrrolo[3,2-b]pyridin-2-one, 6-chloro-1,3-dihydro-;6-Chloro-1,3-dihydro-2H-pyrrolo[3,2-b]pyridin-2-one;6-chloro-1H,2H,3H-pyrrolo[3,2-b]pyridin-2-one
• CAS NO: 136888-12-5
• Molecular Formula: C₇H₅ClN₂O
• Molecular Weight: 168.5804
• Mol File: 136888-12-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 333.8±42.0 °C(Predicted)
• Appearance: /
• Density: 1.450
• Storage Temp.: 2-8°C
• PKA: 12.03±0.20(Predicted)
• CAS DataBase Reference: 6-Chloro-4-aza-2-oxindoie(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloro-4-aza-2-oxindoie(136888-12-5)
• EPA Substance Registry System: 6-Chloro-4-aza-2-oxindoie(136888-12-5)

Safety Data

• Hazardous Substances Data: 136888-12-5(Hazardous Substances Data)

Usage

General Description

6-Chloro-4-aza-2-oxindoie, also known as 6-chloro-4-azaindol-2-one, is a chemical compound with the molecular formula C8H5ClN2O. It is a heterocyclic compound containing an indole ring with a chlorine atom and a nitrogen atom in the 4 and 6 positions, respectively. 6-Chloro-4-aza-2-oxindoie has been studied for its potential use in pharmaceuticals and agrochemicals, as it exhibits biological activity and can be used as a building block for synthesizing other organic compounds. Its structure and properties make it a valuable tool in medicinal and chemical research, and it has potential applications in the development of new drugs and other commercial products.

Upstream product

• 1072-98-6 5-chloro-2-pyridylamine 
• 75806-86-9 2-bromo-5-chloro-3-nitropyridine 
• 5409-39-2 2-amino-5-chloro-3-nitropyridine 
• 21427-62-3 2,5-dichloro-3-nitropyridine 
• 136888-14-7 3-amino-2-bis(ethoxycarbonyl)methyl-5-chloropyridine 
• 136888-13-6 diethyl (5-chloro-3-nitropyridin-2-yl )propanedioate 

Downstream Products

• 1360821-97-1 E/Z-6-chloro-3-(3-chloro-2-fluoro-benzylidene)-1,3-dihydro-pyrrolo[3,2-b]pyridin-2-one 
• 1360821-40-4 chiral(2S,3S,4S,5R)-6'-chloro-4-(3-chloro-2-fluorophenyl)-N-(4-(2-hydroxyethoxy)-2-methoxyphenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-b]pyridine]-5-carboxamide 
• 1360822-13-4 chiral(2R,3R,4R,5S)-6'-chloro-4-(3-chloro-2-fluorophenyl)-N-(4-(2-hydroxyethoxy)-2-methoxyphenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-b]pyridine]-5-carboxamide 

Relevant articles and documents

SPIRO-SUBSTITUTED OXINDOLE DERIVATIVES HAVING AMPK ACTIVITY

The present invention relates to compounds of formula (I), which have valuable pharmacological properties, in particular are activators of AMPK and which are therefore useful in the treatment of certain disorders that can be prevented or treated by activation of this receptor. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.

Azaoxindole derivatives

This invention relates to novel 4-, 5-, 6-, and 7-azaoxindole derivatives. The compounds are anti-inflammatory and analgesic agents and inhibitors of one or more of prostaglandin H2 synthase, 5-lipoxygenase and interleukin-1 biosynthesis. They are useful in the treatment of chronic inflammatory diseases, allergy, psoriasis, various bone diseases, and immune dysfunctions such as systemic lupus erythematosis.

Azaoxindole derivatives

This invention relates to novel 4-, 5-, 6-, and 7-azaoxindole derivatives. The compounds are anti-inflammatory and analgesic agents and inhibitors of one or more of prostaglandin H2 synthase, 5-lipoxygenase and interleukin-1 biosynthesis. They are useful in the treatment of chronic inflammatory diseases, allergy, psoriasis, various bone diseases, and immune dysfunctions such as systemic lupus erythematosis.