136901-10-5

Basic information

• Product Name: 2-AMINO-6-CHLORO-3-NITROPYRIDINE
• Synonyms: 2-AMINO-3-NITRO-6-CHLOROPYRIDINE;LABOTEST-BB LT00012599;2-AMino-6-Chloro-3-Nitopyridine
• CAS NO: 136901-10-5
• Molecular Formula: C5H4ClN3O2
• Molecular Weight: 173.56
• EINECS: 1592732-453-0
• Product Categories: Amines;blocks;NitroCompounds;Pyridines;Pyridines, Pyrimidines, Purines and Pteredines
• Mol File: 136901-10-5.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 339.9ºC at 760 mmHg
• Flash Point: 159.4ºC
• Appearance: /
• Density: 1.596g/cm3
• Vapor Pressure: 8.89E-05mmHg at 25°C
• Refractive Index: 1.657
• CAS DataBase Reference: 2-AMINO-6-CHLORO-3-NITROPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-6-CHLORO-3-NITROPYRIDINE(136901-10-5)
• EPA Substance Registry System: 2-AMINO-6-CHLORO-3-NITROPYRIDINE(136901-10-5)

Safety Data

• Hazardous Substances Data: 136901-10-5(Hazardous Substances Data)

Usage

General Description

2-Amino-6-chloro-3-nitropyridine is an organic compound with the molecular formula C5H4ClN3O2. It is a nitroaromatic compound that contains both an amino and a nitro group, as well as a chloro substituent on the pyridine ring. 2-AMINO-6-CHLORO-3-NITROPYRIDINE is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals, as well as in the production of dyes and pigments. It is also utilized in the manufacturing of other organic compounds, such as heterocyclic compounds, which are widely used in the pharmaceutical industry. Additionally, 2-amino-6-chloro-3-nitropyridine has been shown to possess antimicrobial and antifungal properties, making it a potentially valuable chemical for medical and agricultural applications.

InChI:InChI=1/C5H4ClN3O2/c6-4-2-1-3(9(10)11)5(7)8-4/h1-2H,(H2,7,8)

Upstream product

• 120-43-4 4-ethoxycarbonylpiperazine 
• 148493-34-9 (2,6-dichloropyridin-3-yl)boronic acid 
• 16013-84-6 2,6-dihydroxy-3-nitropyridine 
• 2402-78-0 2,6-dichloropyridine 

Downstream Products

• 33742-70-0 6-chloro-N-methyl-3-nitropyridin-2-amine 
• 102266-32-0 S,S-Dimethyl-N-(3-nitro-6-phenylthio-2-pyridyl)schwefeldiimid 
• 102266-34-2 N-(6-Chlor-3-nitro-2-pyridyl)-S,S-dimethyl-N'-(4-nitrobenzoyl)schwefeldiimid 
• 40851-92-1 5-chloro-2-methylimidazo<4,5-b>pyridine 
• 139086-97-8 2-acetamido-6-chloro-3-nitropyridine 
• 33742-69-7 6-chloro-N-ethyl-3-nitropyridin-2-amine 
• 1313881-59-2 tert-butyl (1-(4-(5-(3-acetamidophenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo[4,5-b]pyridin-3-yl)phenyl)cyclobutyl)carbamate 
• 1094323-19-9 2-chloro-6-ethoxy-5-nitropyridine 
• 1326703-79-0 2-chloro-6-isopropoxy-3-nitropyridine 
• 1326703-80-3 C₁₁H₁₆N₂O₄ 
• 186413-77-4 6-chloro-3-nitro-2-(propan-2-yloxy)pyridine 
• 1360541-25-8 C₁₃H₁₃ClN₄O₂ 
• 1096945-36-6 C₁₂H₇ClF₃N₃O₂ 
• 1331741-76-4 C₁₇H₁₉N₅O 

Relevant articles and documents

REACTIVITIES OF HETEROCYCLIC COMPOUNDS IN NITRATION. 7. EXPERIMENTAL AND THEORETICAL STUDY OF THE REACTIVITIES OF PYRIDINES

The relationship between the rates of nitration of pyridines and the calculated indexes of aromatic electrophilic substitution was investigated.The possibility of the use of two-center components of the location energies for the theoretical description of the reactivities of pyridines in nitration is demonstrated.The rates of nitration of a number of previously uninvestigated pyridines are predicted.

Optimization of 4,6-Disubstituted Pyrido[3,2-d]pyrimidines as Dual MNK/PIM Inhibitors to Inhibit Leukemia Cell Growth

Mitogen-activated protein kinase-interacting kinases (MNKs) and provirus integration in maloney murine leukemia virus kinases (PIMs) are downstream enzymes of cell proliferation signaling pathways associated with the resistance of tyrosine kinase inhibitors. MNKs and PIMs have complementary effects to regulate cap-dependent translation of oncoproteins. Dual inhibitors of MNKs and PIMs have not been developed. We developed a novel 4,6-disubstituted pyrido[3,2-d]pyrimidine compound 21o with selective inhibition of MNKs and PIMs. The IC50’s of 21o to inhibit MNK1 and MNK2 are 1 and 7 nM and those to inhibit PIM1, PIM2, and PIM3 are 43, 232, and 774 nM, respectively. 21o inhibits the growth of myeloid leukemia K562 and MOLM-13 cells with GI50’s of 2.1 and 1.2 μM, respectively. 21o decreases the levels ofp-eIF4E andp-4EBP1, the downstream products of MNKs and PIMs, as well as cap-dependent proteins c-myc, cyclin D1, and Mcl-1. 21o inhibits the growth of MOLM-13 cell xenografts without causing evident toxicity. 21o represents an innovative dual MNK/PIM inhibitor with a good pharmacokinetic profile.

NITRATION

The present invention relates to a process for preparing a nitrated compound, comprising the step of reacting a compound (A) comprising at least one substituted or unsubstituted aromatic or heteroaromatic ring, wherein said heteroaromatic ring comprises at least one heteroatom selected from the group consisting of oxygen, sulfur, phosphor, selenium and nitrogen, with a compound of formula (I) wherein Y is selected from the group consisting of hydrogen and nitro.

Preparation method of 2,6-dichloro-3-nitropyridine

The invention relates to a 2,6-Dichloro-3-Preparation method of nitropyridine. The method uses 2-Nitroacetate and 2-Halogenated acrylates are catalyzed by organic bases for 1,4-Addition reaction followed by cyclization reaction with ammonia to obtain 2,6-Dihydroxy-3-Nitropyridine is then reacted with a chlorinating reagent to produce 2,6-Dichloro-3-Nitropyridine. The invention does not use concentrated sulfuric acid and nitric acid, the used raw materials are cheap and easily available, the operation is simple and convenient, the conditions are mild, the amount of waste water is small, the invention is safe and environment-friendly and the cost is low.