1369344-14-8 Usage
Description
1-(2,3-dichlorophenyl)-1H-pyrazole-4-carboxylic acid is a chemical compound with a molecular formula C10H6Cl2N2O2. It is a pyrazole derivative and a carboxylic acid, known for its potential applications in the pharmaceutical and agrochemical industries due to its biological activities.
Uses
Used in Pharmaceutical Industry:
1-(2,3-dichlorophenyl)-1H-pyrazole-4-carboxylic acid is used as an intermediate in the synthesis of various pharmaceuticals for its potential anti-inflammatory and analgesic properties. Its chemical structure allows for further modification and development of new drugs targeting specific conditions.
Used in Agrochemical Industry:
In the agrochemical industry, 1-(2,3-dichlorophenyl)-1H-pyrazole-4-carboxylic acid is utilized as an intermediate in the development of compounds with pesticidal or herbicidal properties, contributing to enhanced crop protection and yield.
Used in Anticancer Research:
1-(2,3-dichlorophenyl)-1H-pyrazole-4-carboxylic acid is investigated as a potential anticancer agent, with its structure and properties being studied for their effects on cancer cell growth and proliferation. Its integration into drug development pipelines may lead to the creation of novel therapeutics for cancer treatment.
Used in Research and Development:
1-(2,3-dichlorophenyl)-1H-pyrazole-4-carboxylic acid's structure and properties make it a valuable asset in various fields of research and development, particularly in the synthesis and study of new molecules with potential applications in medicine and agriculture. Its versatility as a chemical intermediate opens up possibilities for the creation of innovative products and solutions.
Check Digit Verification of cas no
The CAS Registry Mumber 1369344-14-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,6,9,3,4 and 4 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1369344-14:
(9*1)+(8*3)+(7*6)+(6*9)+(5*3)+(4*4)+(3*4)+(2*1)+(1*4)=178
178 % 10 = 8
So 1369344-14-8 is a valid CAS Registry Number.
1369344-14-8Relevant articles and documents
Potent, Orally Bioavailable, and Efficacious Macrocyclic Inhibitors of Factor XIa. Discovery of Pyridine-Based Macrocycles Possessing Phenylazole Carboxamide P1 Groups
Corte, James R.,Pinto, Donald J. P.,Fang, Tianan,Osuna, Honey,Yang, Wu,Wang, Yufeng,Lai, Amy,Clark, Charles G.,Sun, Jung-Hui,Rampulla, Richard,Mathur, Arvind,Kaspady, Mahammed,Neithnadka, Premsai Rai,Li, Yi-Xin Cindy,Rossi, Karen A.,Myers, Joseph E.,Sheriff, Steven,Lou, Zhen,Harper, Timothy W.,Huang, Christine,Zheng, Joanna J.,Bozarth, Jeffrey M.,Wu, Yiming,Wong, Pancras C.,Crain, Earl J.,Seiffert, Dietmar A.,Luettgen, Joseph M.,Lam, Patrick Y. S.,Wexler, Ruth R.,Ewing, William R.
supporting information, p. 784 - 803 (2020/02/04)
Factor XIa (FXIa) inhibitors are promising novel anticoagulants, which show excellent efficacy in preclinical thrombosis models with minimal effects on hemostasis. The discovery of potent and selective FXIa inhibitors which are also orally bioavailable has been a challenge. Here, we describe optimization of the imidazole-based macrocyclic series and our initial progress toward meeting this challenge. A two-pronged strategy, which focused on replacement of the imidazole scaffold and the design of new P1 groups, led to the discovery of potent, orally bioavailable pyridine-based macrocyclic FXIa inhibitors. Moreover, pyridine-based macrocycle 19, possessing the phenylimidazole carboxamide P1, exhibited excellent selectivity against relevant blood coagulation enzymes and displayed antithrombotic efficacy in a rabbit thrombosis model.
