1369583-90-3

Basic information

• Product Name: N-[4-(4-(2-methoxyphenylpiperazinyl)butyryl)]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine
• Synonyms: N-[4-(4-(2-methoxyphenylpiperazinyl)butyryl)]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine
• CAS NO: 1369583-90-3
• Molecular Weight: 557.757
• Mol File: 1369583-90-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[4-(4-(2-methoxyphenylpiperazinyl)butyryl)]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-(4-(2-methoxyphenylpiperazinyl)butyryl)]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine(1369583-90-3)
• EPA Substance Registry System: N-[4-(4-(2-methoxyphenylpiperazinyl)butyryl)]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine(1369583-90-3)

Safety Data

• Hazardous Substances Data: 1369583-90-3(Hazardous Substances Data)

Upstream product

• 116817-13-1 duloxetine 
• 34772-98-0 3-dimethylamino-1-thiophen-2-ylpropenone 
• 1049751-94-1 N-methyl-N-ethyloxyacyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine 
• 35386-24-4 1-(2-Methoxyphenyl)piperazine 
• 1369583-83-4 C₂₂H₂₄ClNO₂S 
• 13636-02-7 3-(N,N-dimethylamino)-1-(thien-2-yl)propan-1-ol 
• 88-15-3 2-Acetylthiophene 

Downstream Products

• 1369583-96-9 N-[4-(4-(2-methoxyphenylpiperazinyl))butyl]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine 

Relevant articles and documents

Synthesis and dual 5-ht1a/ssri activities of some novel arylpiperazine derivatives of duloxetine

A series of novel arylpiperazine derivatives of duloxetine were designed and synthesized from the key intermediate 5 by acylation, alkylation and reduction based on 5-HT1A/SSRI drugs design strategies. Compound 5 was obtained through the reaction sequence including condensation, reduction, O-etherification, Von Braun reaction, hydrolysis reaction. Structures of the synthesized compounds were confirmed by MS, 1H NMR and HRMS. Furthermore, these compounds were evaluated for their dual 5-HT1A/5-HTT activities. The results indicated that all the compounds exhibited certain affinity to 5-HTT and 5-HT1A receptor.