137-86-0

Basic information

• Product Name: OCTOTIAMINE
• Synonyms: OCTOTIAMINE;gerostop;neuvitan;octanoicacid,6-(acetylthio)-8-((2-(((4-amino-2-methyl-5-pyrimidinyl)methyl)fo;Octotiamina [INN-Spanish];Octanoic acid, 6-(acetylthio)-8-[[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-(2-hydroxyethyl)-1-propenyl]dithio]-, methyl ester (9CI);octiamine;S-(3-Acetylthio-7-carbomethoxyheptylthio)thiamine
• CAS NO: 137-86-0
• Molecular Formula: C23H36N4O5S3
• Molecular Weight: 544.75
• Mol File: 137-86-0.mol
• Article Data: 0

Chemical Properties

• Melting Point: 106-109°
• Boiling Point: 722°Cat760mmHg
• Flash Point: 390.5°C
• Appearance: /
• Density: 1.1973 (rough estimate)
• Vapor Pressure: 7.03E-22mmHg at 25°C
• Refractive Index: 1.5960 (estimate)
• CAS DataBase Reference: OCTOTIAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: OCTOTIAMINE(137-86-0)
• EPA Substance Registry System: OCTOTIAMINE(137-86-0)

Safety Data

• Hazardous Substances Data: 137-86-0(Hazardous Substances Data)

Usage

Description

Octotiamine, a derivative of Vitamin B1, is a potent inhibitor of 11β-hydroxysteroid dehydrogenase. It is a compound with significant pharmaceutical applications due to its ability to modulate the activity of this enzyme, which plays a crucial role in various physiological processes.

Uses

Used in Pharmaceutical Industry:
Octotiamine is used as an inhibitor for 11β-hydroxysteroid dehydrogenase to regulate the conversion of active cortisol to its inactive form, cortisone. This modulation of enzyme activity has potential therapeutic applications in treating conditions related to cortisol imbalance, such as Cushing's syndrome and other endocrine disorders.
Additionally, due to its inhibitory effects on 11β-hydroxysteroid dehydrogenase, Octotiamine may also have implications in the treatment of obesity and type 2 diabetes, as these conditions are often associated with altered cortisol metabolism.
Used in Research Applications:
In the field of scientific research, Octotiamine serves as a valuable tool for studying the role of 11β-hydroxysteroid dehydrogenase in various biological processes. By inhibiting this enzyme, researchers can gain insights into the underlying mechanisms of cortisol action and its impact on health and disease.
Furthermore, Octotiamine's inhibitory properties can be utilized in the development of novel drug delivery systems and formulations, aiming to improve the efficacy and bioavailability of other therapeutic agents that target the same enzyme or related pathways.

InChI:InChI=1/C23H36N4O5S3/c1-16(27(15-29)14-19-13-25-17(2)26-23(19)24)21(9-11-28)35-33-12-10-20(34-18(3)30)7-5-6-8-22(31)32-4/h13,15,20,28H,5-12,14H2,1-4H3,(H2,24,25,26)/b21-16+