1370438-57-5 Usage
Description
(1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamide is a chemical compound that serves as an analogue of Tadalafil (T004500), a human PDE5 inhibitor. (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamide is characterized by its unique molecular structure, which includes a benzo[d][1,3]dioxol-5-yl group and a tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamide moiety. It also exhibits weak inhibitory activity against TbrPDEB1.
Uses
Used in Pharmaceutical Industry:
(1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamide is used as a PDE5 inhibitor for the treatment of erectile dysfunction. As an analogue of Tadalafil, it has the potential to improve blood flow to the penis, aiding in achieving and maintaining an erection.
Additionally, due to its weak inhibitory activity against TbrPDEB1, this compound may have potential applications in the development of new therapeutic strategies for various diseases and conditions where PDE5 inhibition could be beneficial.
Used in Research and Development:
In the field of research and development, (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamide can be utilized as a starting point for the synthesis of new compounds with improved pharmacological properties. Its unique structure and activity profile make it a valuable tool for exploring novel therapeutic approaches and understanding the underlying mechanisms of PDE5 inhibition.
Check Digit Verification of cas no
The CAS Registry Mumber 1370438-57-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,7,0,4,3 and 8 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1370438-57:
(9*1)+(8*3)+(7*7)+(6*0)+(5*4)+(4*3)+(3*8)+(2*5)+(1*7)=155
155 % 10 = 5
So 1370438-57-5 is a valid CAS Registry Number.
1370438-57-5Relevant articles and documents
Synthesis and evaluation of human phosphodiesterases (PDE) 5 inhibitor analogs as trypanosomal PDE inhibitors. Part 2. Tadalafil analogs
Ochiana, Stefan O.,Gustafson, Alden,Bland, Nicholas D.,Wang, Cuihua,Russo, Michael J.,Campbell, Robert K.,Pollastri, Michael P.
supporting information; experimental part, p. 2582 - 2584 (2012/05/05)
In this Letter we describe our ongoing target repurposing efforts focused on discovery of inhibitors of the essential trypanosomal phosphodiesterase TbrPDEB1. This enzyme has been implicated in virulence of Trypanosoma brucei, the causative agent of human African trypanosomiasis (HAT). We outline the synthesis and biological evaluation of analogs of tadalafil, a human PDE5 inhibitor currently utilized for treatment of erectile dysfunction, and report that these analogs are weak inhibitors of TbrPDEB1.
