1370522-61-4

Basic information

• Product Name: 5-hydroxy-2-phenyl-7-(p-tolyl)-4H-chromen-4-one
• Synonyms: 5-hydroxy-2-phenyl-7-(p-tolyl)-4H-chromen-4-one
• CAS NO: 1370522-61-4
• Molecular Weight: 328.367
• Mol File: 1370522-61-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-hydroxy-2-phenyl-7-(p-tolyl)-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-hydroxy-2-phenyl-7-(p-tolyl)-4H-chromen-4-one(1370522-61-4)
• EPA Substance Registry System: 5-hydroxy-2-phenyl-7-(p-tolyl)-4H-chromen-4-one(1370522-61-4)

Safety Data

• Hazardous Substances Data: 1370522-61-4(Hazardous Substances Data)

Upstream product

• 5720-05-8 4-methylphenylboronic acid 
• 109586-45-0 trifluoromethanesulfonic acid 5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl ester 
• 480-40-0 5,7-dihydroxy-2-phenyl-chromen-4-one 

Relevant articles and documents

Synthesis of Flavone Derivatives through Versatile Palladium-Catalyzed Cross-Coupling Reactions of Tosyloxy- and Mesyloxyflavones

Tosyloxy- and mesyloxyflavones derived from abundant and biologically important hydroxyflavones were used to synthesize a series of functionalized flavones through versatile palladium-catalyzed cross-coupling reactions. A Pd(OAc) 2 /2-[2-(dicyclohexylphosphino)phenyl]-1-methyl-1 H -indole system effectively catalyzed the reactions of a broad range of tosyloxy- and mesyloxyflavones as electrophilic coupling partners with various nucleophiles to give the corresponding products in good to excellent yields. Catalyst loadings of as little as 0.1 mol% Pd were successfully used. Importantly, we demonstrated that this protocol provided a significantly improved efficiency in the synthesis of a potential chromen-4-one-based analogue of a potent inhibitor of DNA-dependent protein kinase.