1370618-85-1

Basic information

• Product Name: 5-methyl-2-(4-tirfluoromethoxy[1,1':4',1''-terphenyl]-4-yl)-1H-benzo[d]imidazole
• Synonyms: 5-methyl-2-(4-tirfluoromethoxy[1,1':4',1''-terphenyl]-4-yl)-1H-benzo[d]imidazole
• CAS NO: 1370618-85-1
• Molecular Weight: 444.456
• Mol File: 1370618-85-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-methyl-2-(4-tirfluoromethoxy[1,1':4',1''-terphenyl]-4-yl)-1H-benzo[d]imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methyl-2-(4-tirfluoromethoxy[1,1':4',1''-terphenyl]-4-yl)-1H-benzo[d]imidazole(1370618-85-1)
• EPA Substance Registry System: 5-methyl-2-(4-tirfluoromethoxy[1,1':4',1''-terphenyl]-4-yl)-1H-benzo[d]imidazole(1370618-85-1)

Safety Data

• Hazardous Substances Data: 1370618-85-1(Hazardous Substances Data)

Upstream product

• 50670-58-1 4-formyl-4'-bromobiphenyl 
• 589-87-7 1,4-bromoiodobenzene 
• 1370618-94-2 4-trifluoromethoxy[1,4';1',4]terphenyl-1-carbaldehyde 
• 496-72-0 4-methyl-1,2-diaminobenzene 

Relevant articles and documents

Synthesis of terphenyl benzimidazoles as tubulin polymerization inhibitors

A series of new terphenyl benzimidazoles (3a-z and 3aa-ad) were synthesized and evaluated for their anticancer activity. All the 30 compounds have shown moderate to good anticancer potency, however some of the compounds (3j, 3m-t and 3aa-ad) exhibited prominent anticancer potency with GI50 values ranging from 0.1 to 9.72 μM. These compounds exhibit G2/M phase arrest and the analysis of tubulin by Western blot experiments in case of 3t and 3ad shows the disturbances that are caused in the ratio of soluble versus polymerized tubulin in cells. Compounds 3t and 3ad are the most promising candidates amongst the series and has the potential to be taken up for further detailed studies either alone or in combination with the existing therapies.