137075-14-0

Basic information

• Product Name: 1-Piperazineacetonitrile, a-3-pyridinyl-
• CAS NO: 137075-14-0
• Molecular Formula: C11H14N4
• Molecular Weight: 202.259
• Mol File: 137075-14-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-Piperazineacetonitrile, a-3-pyridinyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperazineacetonitrile, a-3-pyridinyl-(137075-14-0)
• EPA Substance Registry System: 1-Piperazineacetonitrile, a-3-pyridinyl-(137075-14-0)

Safety Data

• Hazardous Substances Data: 137075-14-0(Hazardous Substances Data)

Upstream product

• 5586-73-2 3-diphenylpropyl amine 

Downstream Products

• 137074-84-1 1-(3-(3,4,5-Trimethoxyphenyl)propanoyl)-4-(pyridin-3-ylcyanomethyl)-piperazine 
• 137074-81-8 1-(2-phenylpropanoyl)-4-(pyridin-3-ylcyanomethyl)piperazine 
• 137074-79-4 1-(diphenylacetyl)-4-(pyridin-3-ylcyanomethyl)piperazine 
• 137074-16-9 1-(2,4-Diphenylbutanoyl)-4-(pyridin-3-ylcyanomethyl)piperazine 
• 137074-22-7 1-(3,3-diphenylpropenoyl)-4-(pyridin-3-ylcyanomethyl)piperazine 
• 137074-17-0 1-(3,3-diphenylpropanoyl)-4-(pyridin-3-ylcyanomethyl)piperazine 
• 137074-33-0 1-(3,3-diphenyl-3-hydroxypropanoyl)-4-(pyridin-3-ylcyanomethyl)piperazine 
• 137074-15-8 1-(2,3-Diphenylpropanoyl)-4-(pyridin-3-ylcyanomethyl)piperazine 
• 137074-97-6 {4-[2-(Benzhydryl-amino)-acetyl]-piperazin-1-yl}-pyridin-3-yl-acetonitrile 
• 137074-77-2 1-Benzoyl-4-(pyridin-3-ylcyanomethyl)piperazine 
• 137074-98-7 {4-[2-(Benzhydryl-methyl-amino)-acetyl]-piperazin-1-yl}-pyridin-3-yl-acetonitrile 
• 137074-66-9 1-((N-(3,3-diphenylpropyl)aminocarbonyl)methyl)-4-(pyridin-3-ylcyanomethyl)piperazine 
• 137074-87-4 1-((2,2-diphenylethoxy)carbonyl)-4-(pyridin-3-ylcyanomethyl)piperazine 
• 143817-04-3 {4-[(E)-(3-Phenyl-acryloyl)]-piperazin-1-yl}-pyridin-3-yl-acetonitrile 

Relevant articles and documents

(cyanomethyl)pyridines useful as PAF antagonists

57 The present invention relates to new (cyanomethyl)pyridines of general formula I: wherein Ais nitrogen and Bis -CH-, or Bis nitrogen and Ais -CH-; the group Y-W-represents a group of formula N-CR1(CN)-, N-CH2-CH(CN)-, CH-CH(CN)- or C=C(CN)- wherein R1 is hydrogen or a C1-C6 alkyl group; Rrepresents a group of formula R2CO-,R3R4N-(CH2)nCO- or R5-(CH2)m- wherein R2 represents C1-C15 alkyl, aryl, aryl-(C1-C6)-alkyl, aryl-(C1-C6)-alkenyl, diaryl-(C1-C6)-alkyl, diaryl-(C1-C6)-alkenyl, arylhydroxy-(C1-C6)-alkyl, diarylhydroxy-(C1-C6)-alkyl, aryl-(C1-C6)-alkoxy, diaryl-(C1-C6)-alkoxy, or heteroaryl-(C1-C6)-alkyl group; n is 0, 1, 2 or 3; R3 is hydrogen, C1-C6 alkyl, aryl or aryl-(C1-C6)-alkyl group; R4 is C3-C6 cycloalkyl, aryl, aryl-(C1-C6)-alkyl, diaryl-(C1-C6)-alkyl, aryl-(C1-C6)-alkylcarbonyl or diaryl-(C1-C6)-alkylcarbonyl group; m is 0, 1 or 2; and R5 is aryl-(C1-C6)-alkyl, diaryl-(C1-C6)-alkyl, diaryl-(C1-C6)-alkylcarbonylamino or diaryl-(C1-C6)-alkylaminocarbonyl group. These compounds are potent, orally active PAF antagonists and consequently, useful in the treatment of the diseases in which this substance is involved.