13709-20-1Relevant articles and documents
A β-secretase (BACE1) inhibitor hispidin from the mycelial cultures of Phellinus linteus
Park, In-Hye,Jeon, So-Young,Lee, Hee-Ju,Kim, Sang-In,Song, Kyung-Sik
, p. 143 - 146 (2007/10/03)
In the course of screening for anti-dementia agents from natural products, a β-secretase (BACE1) inhibitor was isolated from the culture broth of Phellinus linteus and identified as hispidin. It showed an IC50 value of 4.9 × 10-6 M and a Ki value of 8.4 × 10 -6 M. The compound was a non-competitive inhibitor. Hispidin also inhibited a prolyl endopeptidase (IC50 = 1.6 × 10-5 M, Ki = 2.4 × 10-5 M), but it was less inhibitory to α-secretase (TACE) and other serine proteases such as chymotrypsin, trypsin, and elastase.