137102-65-9

Basic information

• Product Name: [(1R)-2-AMINO-1-PHENYLETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER
• Synonyms: tert-butyl (R)-(2-amino-1-phenylethyl)carbamate;[(1R)-2-AMINO-1-PHENYLETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER;(R)-2-(Boc-aMino)-2-phenylethylaMine
• CAS NO: 137102-65-9
• Molecular Formula: C₁₃H₂₀N₂O₂
• Molecular Weight: 236.313
• Mol File: 137102-65-9.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 372.2±35.0 °C(Predicted)
• Appearance: /
• Density: 1.066±0.06 g/cm3(Predicted)
• PKA: 11?+-.0.46(Predicted)
• CAS DataBase Reference: [(1R)-2-AMINO-1-PHENYLETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: [(1R)-2-AMINO-1-PHENYLETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER(137102-65-9)
• EPA Substance Registry System: [(1R)-2-AMINO-1-PHENYLETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER(137102-65-9)

Safety Data

• Hazardous Substances Data: 137102-65-9(Hazardous Substances Data)

Usage

Description

[(1R)-2-AMINO-1-PHENYLETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER, with the molecular formula C12H19N3O2, is a chemical compound that is the ester form of [(1R)-2-amino-1-phenylethyl]-carbamic acid. [(1R)-2-AMINO-1-PHENYLETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER holds potential therapeutic applications, particularly in the treatment of neurological disorders. It serves as a reagent in chemical reactions, enabling the formation of new compounds with possible pharmaceutical or industrial applications. Its versatile properties and uses make it an essential tool in chemical research and development, as well as in the pharmaceutical industry for addressing various medical conditions.

Uses

Used in Pharmaceutical Industry:
[(1R)-2-AMINO-1-PHENYLETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER is used as a therapeutic agent for the treatment of neurological disorders due to its potential to alleviate symptoms and improve patient outcomes.
Used in Chemical Research and Development:
[(1R)-2-AMINO-1-PHENYLETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER is used as a reagent in chemical reactions to form new compounds with potential pharmaceutical or industrial uses, contributing to the advancement of scientific knowledge and the creation of novel products.
Used in Drug Synthesis:
[(1R)-2-AMINO-1-PHENYLETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER is utilized as a key component in the synthesis of various drugs, particularly those targeting neurological conditions, due to its unique chemical properties and reactivity.

Upstream product

• 221352-64-3 dicyclohexylammonium (R)-2-((tert-butoxycarbonyl)amino)pent-4-enoate 
• 102-96-5 (2-nitroethenyl)benzene 
• 79722-21-7 tert-butyl N-(benzyloxy)carbamate 
• 1312926-11-6 tert-butyl benzyloxy(2-nitro-1-phenylethyl)carbamate 
• 941602-11-5 tert-butyl N-(2-nitro-1-phenylethyl)carbamate 
• 182160-14-1 2-((S)-1-Hydroxy-2,2-dimethyl-propyl)-3-((S)-2-phenyl-aziridin-1-yl)-3H-quinazolin-4-one 
• 201730-82-7 3-((R)-2-Azido-2-phenyl-ethylamino)-2-((S)-1-hydroxy-2,2-dimethyl-propyl)-3H-quinazolin-4-one 
• 201730-83-8 3-((R)-2-Chloro-2-phenyl-ethylamino)-2-((S)-1-hydroxy-2,2-dimethyl-propyl)-3H-quinazolin-4-one 
• 177896-09-2 tert-butyl benzylidenecarbamate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 155396-71-7 tert-butyl N-(phenyl(phenylsulfonyl)methyl)carbamate 
• 150884-50-7 benzaldehyde N-boc imine 
• 100-52-7 benzaldehyde 
• 4248-19-5 tert-butyl carbazate 

Downstream Products

• 155273-85-1 (R)-(-)-N-<2-<<<2,6-bis(1-methylethyl)phenoxy>carbonyl>amino>-1-phenylethyl>carbamic acid 1,1-dimethylethyl ester 
• 155273-91-9 (R)-(-)-N-<2,6-bis(1-methylethyl)phenyl>-N'-<2-<(butoxycarbonyl)amino>-2-phenylethyl>urea 
• 1078121-41-1 (R)-2-[N,N-di-n-buthylamino]-1-(tert-butoxycarbonyl)amino-1-phenylethane 
• 1078121-40-0 (R)-2-(N,N-diethylamino)-1-(tert-butoxycarbonyl)amino-1-phenylethane 
• 1172596-82-5 tert-butyl (R)-2-isothiocyanato-1-phenylethylcarbamate 

Relevant articles and documents

Preparation method of key intermediate of elagolix

The invention relates to the field of pharmacy, and concretely relates to a preparation method of a key intermediate of elagolix. The method adopts simple and easily available Boc-D-phenylglycinol asa starting material, and comprises the following steps:

SYNTHESIS OF ARYL CYCLOHEXANE CARBOXAMIDE DERIVATIVES USEFUL AS SENSATES IN CONSUMER PRODUCTS

Synthesis methods to produce a series of carboxamides built off of an (S)-2-amino acid backbone or an (R)-2-amino acid backbone, depending upon the desired diastereomer of the end product.

Design of substituted imidazolidinylpiperidinylbenzoic acids as chemokine receptor 5 antagonists: Potent inhibitors of R5 HIV-1 replication

The redesign of the previously reported thiophene-3-yl-methyl urea series, as a result of potential cardiotoxicity, was successfully accomplished, resulting in the identification of a novel potent series of CCR5 antagonists containing the imidazolidinylpiperidinyl scaffold. The main redesign criteria were to reduce the number of rotatable bonds and to maintain an acceptable lipophilicity to mitigate hERG inhibition. The structure-activity relationship (SAR) that was developed was used to identify compounds with the best pharmacological profile to inhibit HIV-1. As a result, five advanced compounds, 6d, 6e, 6i, 6h, and 6k, were further evaluated for receptor selectivity, antiviral activity against CCR5 using (R5) HIV-1 clinical isolates, and in vitro and in vivo safety. On the basis of these results, 6d and 6h were selected for further development.