137131-14-7Relevant articles and documents
A convenient preparation of 3,3,3-trifluoro-1-propynylamines and their Lewis acid catalyzed reaction with carbonyl compounds leading to (Z)-α-(trifluoromethyl)-α,β-unsaturated amides
Mantani,Shiomi,Konno,Ishihara,Yamanaka
, p. 3442 - 3448 (2001)
N,N-Dialkyl(3,3,3-trifluoro-1-propynyl)amines were readily prepared by a three-step procedure starting from commercially available 2,2,3,3,3-pentafluoropropanol. These fluorinated alkynylamines reacted smoothly with a variety of aldehydes or ketones in the presence of a catalytic amount of Lewis acid and molecular sieves 4A at ambient temperature to produce the corresponding α(trifluoromethyl)-α,β-unsaturated amides in good to excellent yields with high Z-stereoselectivity.
