13721-39-6 Usage
Description
Sodium orthovanadate, also known as Na3VO4, is a white to off-white powder with chemical properties that make it a versatile compound in various industries. It is an alkaline phosphatase and (Na,K)-ATPase inhibitor with an IC50 of 10 μM and acts as a general inhibitor of tyrosine phosphatases, a large family of enzymes that catalyze the removal of phosphate groups from tyrosine residues.
Uses
Used in Pharmaceutical Industry:
Sodium orthovanadate is used as an inhibitor for various phosphatases and kinases, playing a crucial role in the development and research of pharmaceuticals targeting these enzymes. Its ability to inhibit tyrosine phosphatases makes it a valuable compound in the study and treatment of various diseases and conditions.
Used in Catalyst Synthesis:
Sodium orthovanadate is used as a metal precursor in the synthesis of various catalysts, such as Vanadium-MCM-48 (V-MCM-48) by anion-exchange method. V-MCM-48 is utilized as a catalyst in the oxidation of styrene to benzaldehyde, a significant process in the chemical industry.
Used in Nanomaterial Synthesis:
Sodium orthovanadate is employed in the synthesis of nanorods of vanadium oxide particles through the glycothermal method. These nanorods have potential applications in various fields, including electronics, energy storage, and catalysis.
Used in Material Science:
Sodium orthovanadate is used in the synthesis of yttrium vanadate (YVO4) doped with colloidal europium. Sodium orthovanadate has potential applications in the field of optics, particularly in the development of phosphors and other light-emitting materials.
Biological Activity
Inhibitor of protein tyrosine phosphatases, alkaline phosphatases and ATPases.
Biochem/physiol Actions
Sodium orthovandate suppresses the activation of p53-mediated apoptosis triggered in response to radiation. It reduces the detrimental effects of hematopoietic syndrome, hematopoiesis and delayed genotoxic effects of induced by total body irradiation of mice.24 In combination with menadione, orthovandate prevents the migration of detached human glioma cells in response to anti-cancer drugs.25
Safety Profile
Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of VOx and NazO. See also VANADIUM COMPOUNDS.
Check Digit Verification of cas no
The CAS Registry Mumber 13721-39-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,7,2 and 1 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 13721-39:
(7*1)+(6*3)+(5*7)+(4*2)+(3*1)+(2*3)+(1*9)=86
86 % 10 = 6
So 13721-39-6 is a valid CAS Registry Number.
InChI:InChI=1/3Na.4O.V/q3*+1;;;;;-3/r3Na.O4V/c;;;1-5(2,3)4/q3*+1;-3