1372716-04-5Relevant articles and documents
A short, chemo-enzymatic synthesis of both enantiomers of trans-3-hydroxypipecolic acid
Begliomini, Stefano,Sernissi, Lorenzo,Scarpi, Dina,Occhiato, Ernesto G.
, p. 5448 - 5455,8 (2014)
A short synthesis of both enantiomers of trans-3-hydroxypipecolic acid was based on the Suzuki-Miyaura reaction of a lactam-derived enol phosphate and the lipase-catalyzed kinetic resolution of the alcohol obtained by hydroboration/oxidation of the coupling product. The RuCl3-catalyzed oxidation of the heteroaryl group introduced by the Suzuki-Miyaura coupling eventually afforded, in six or seven steps, the target compounds in 15-17% overall yield.
Annulated N-Heterocycles by Tandem Gold(I)-Catalyzed [3,3]-Rearrangement/Nazarov Reaction of Propargylic Ester Derivatives: An Experimental and Computational Study
Petrovic, Martina,Scarpi, Dina,Fiser, Béla,G?mez-Bengoa, Enrique,Occhiato, Ernesto G.
, p. 3943 - 3956 (2015/06/30)
The gold(I)-catalyzed tandem rearrangement/Nazarov reaction of propargylic ester derivatives is a useful strategy for the synthesis of cyclopenta-fused N-heterocyclic structures present in many natural compounds. Readily available lactams are converted in
Synthesis of vinylogous amides by gold(I)-catalyzed cyclization of N-boc-protected 6-alkynyl-3,4-dihydro-2H-pyridines
Oppedisano, Alberto,Prandi, Cristina,Venturello, Paolo,Deagostino, Annamaria,Goti, Giulio,Scarpi, Dina,Occhiato, Ernesto G.
, p. 11007 - 11016 (2013/11/19)
The gold(I)-catalyzed cyclization of N-Boc-protected 6-alkynyl-3,4-dihydro- 2H-pyridines, prepared by the Sonogashira coupling of lactam-derived enol triflates or phosphates, provides vinylogous amides, which are useful intermediates in the synthesis of n
