1372794-58-5

Basic information

• Product Name: methyl 2-amino-5-[2-(3-benzoylphenyl)propanamido]-5-oxopentanoate
• CAS NO: 1372794-58-5
• Molecular Weight: 396.443
• Mol File: 1372794-58-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 2-amino-5-[2-(3-benzoylphenyl)propanamido]-5-oxopentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-amino-5-[2-(3-benzoylphenyl)propanamido]-5-oxopentanoate(1372794-58-5)
• EPA Substance Registry System: methyl 2-amino-5-[2-(3-benzoylphenyl)propanamido]-5-oxopentanoate(1372794-58-5)

Safety Data

• Hazardous Substances Data: 1372794-58-5(Hazardous Substances Data)

Upstream product

• 32668-14-7 L-glutamine methyl ester monohydrochloride 
• 59512-44-6 ketoprofen chloride 

Relevant articles and documents

Synthesis, characterization and pharmacological evaluation of amino acid conjugates of ketoprofen

Ketoprofen is used for its antipyretic, analgesic and antiinflammatory properties by inhibiting cyclooxygenase-1 and cyclooxygenase-2 enzymes reversibly, which decreases production of proinflammatory prostaglandin precursors. Ketoprofen suffers from the general side effects of nonsteroidal antiinflammatory drugs, owing to presence of free carboxylic acid group. The study aimed to retard the adverse effects of gastrointestinal origin. Different conjugates of ketoprofen have been synthesized by amidation with methyl esters of amino acids namely, phenylalanine, lysine, arginine, glycine, cysteine, valine, glutamine, serine, proline and alanine. Synthesized conjugates were characterized and evaluated for analgesic and antiinflammatory activities.