1372937-21-7Relevant articles and documents
4-OH-tamoxifen cyclic derivative hypoxic activated prodrugs and pharmaceutical application thereof
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Paragraph 0022-0028, (2018/03/01)
The invention relates to 4-OH-tamoxifen cyclic derivative hypoxic activated prodrugs and pharmaceutical application thereof. The structure is as shown in Formula I, wherein, R is -O- or -S-, R is -H, and R is -C2H5, or R and R are connected to form a cyclic structure. The drugs can release Endoxifen or cyclic derivatives thereof under hypoxic conditions, and can be used for preparing drugs for treating tumors.