1373038-60-8 Usage
Description
Valdecoxib IMpurity B is a dimeric impurity derived from the cyclooxygenase-2 (COX-2) inhibitor, Valdecoxib (V090000). It is formed as a byproduct during the synthesis process of Valdecoxib and is characterized by its distinct chemical structure and properties.
Uses
Used in Pharmaceutical Industry:
Valdecoxib IMpurity B is used as a reference material for the development and validation of analytical methods in the pharmaceutical industry. It helps in the identification, quantification, and quality control of Valdecoxib in drug products, ensuring the safety and efficacy of the final product.
Used in Research and Development:
Valdecoxib IMpurity B serves as an important compound in the research and development of new drugs and drug delivery systems. It can be used to study the effects of impurities on the pharmacological properties of Valdecoxib and to develop strategies for minimizing their impact on drug performance.
Used in Quality Control and Regulatory Compliance:
Valdecoxib IMpurity B is used as a critical component in the quality control processes and regulatory compliance of Valdecoxib-containing drug products. It aids in the establishment of acceptable impurity levels and the development of robust specifications to maintain the overall quality of the drug.
Used in Toxicology Studies:
Valdecoxib IMpurity B can be utilized in toxicology studies to evaluate the potential adverse effects of the impurity on human health. This information is crucial for assessing the safety profile of Valdecoxib and setting appropriate safety margins for its use in clinical practice.
Check Digit Verification of cas no
The CAS Registry Mumber 1373038-60-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,7,3,0,3 and 8 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1373038-60:
(9*1)+(8*3)+(7*7)+(6*3)+(5*0)+(4*3)+(3*8)+(2*6)+(1*0)=148
148 % 10 = 8
So 1373038-60-8 is a valid CAS Registry Number.
1373038-60-8Relevant articles and documents
Application of [3+2]-cycloaddition in the synthesis of valdecoxib
Reddy, Anumula Raghupathi,Goverdhan, Gilla,Sampath, Aalla,Mukkanti, Khagga,Reddy, Padi Pratap,Bandichhor, Rakeshwar
, p. 639 - 649 (2012)
A large scale synthesis of valdecoxib 1 is described. Our work features potential application of [3+2]-dipolar cycloaddition involving enamine and in situ-generated nitrile oxide derivatives. Dr. Reddy's Laboratories Ltd.
