1373138-82-9Relevant articles and documents
Isoleucine-catalyzed direct asymmetric aldol addition of enolizable aldehydes
Rohr, Kerstin,Mahrwald, Rainer
supporting information; experimental part, p. 2180 - 2183 (2012/07/13)
Isoleucine-catalyzed direct enantioselective aldol additions between enolizable aldehydes are reported. Intermediate acetal structures dictate the configurative outcome and were supported by a hydrogen bond. This direct isoleucine-catalyzed aldol addition represents a welcome complement to both proline- and histidine-catalyzed aldol additions of enolizable aldehydes.