1373220-65-5

Basic information

• Product Name: C₂₆H₂₂FNO₃
• Synonyms: C₂₆H₂₂FNO₃
• CAS NO: 1373220-65-5
• Molecular Weight: 415.464
• Mol File: 1373220-65-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₆H₂₂FNO₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₆H₂₂FNO₃(1373220-65-5)
• EPA Substance Registry System: C₂₆H₂₂FNO₃(1373220-65-5)

Safety Data

• Hazardous Substances Data: 1373220-65-5(Hazardous Substances Data)

Upstream product

• 108-46-3 recorcinol 
• 13087-18-8 2,2',4-Trihydroxybenzophenone 
• 3722-51-8 3-hydroxyxanthen-9-one 
• 1373220-60-0 4-(allyl(4-fluorobenzyl)amino)-3-(allyloxy)-9H-xanthen-9-one 
• 1373220-50-8 4-(allylamino)-3-(allyloxy)-9H-xanthen-9-one 
• 81008-66-4 4-amino-3-hydroxy-9H-xanthen-9-one 
• 69169-88-6 3-hydroxy-4-nitro-9H-xanthen-9-one 

Relevant articles and documents

Synthesis and evaluation of novel aza-caged Garcinia xanthones

Inspired by the therapeutic potential of the simplified caged xanthones, we have developed a chemical strategy for synthesizing novel aza-caged Garcinia analogues through a regioselective Claisen/Diels-Alder cascade reaction. The origin of regioselectivity has been explained using the DFT method. We have further evaluated the cell proliferation and IKKβ inhibitory activities of these compounds and studied their binding mode with IKKβ by molecular docking. The results suggested that the aza-caged scaffold provides a suitable modification site and the introduction of a hydrophobic moiety leads to improvement in the cytotoxicity and IKKβ inhibitory activity. The aza-caged compound 6c exhibited an IC50 value of 2.68, 2.10, 8.02 μM against the HepG2, A549 cells and IKKβ, respectively. Mechanism studies with 6c showed that the aza-caged compounds induce apoptosis and cell cycle S phase arrest in A549 cells.