1373432-58-6

Basic information

• Product Name: (S)-tert-butyl-4-((2-(1H-indol-3-yl)ethyl)(((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)amino)-2-((tert-butoxycarbonyl) amino)butanoate
• Synonyms: (S)-tert-butyl-4-((2-(1H-indol-3-yl)ethyl)(((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)amino)-2-((tert-butoxycarbonyl) amino)butanoate
• CAS NO: 1373432-58-6
• Molecular Weight: 706.842
• Mol File: 1373432-58-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-tert-butyl-4-((2-(1H-indol-3-yl)ethyl)(((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)amino)-2-((tert-butoxycarbonyl) amino)butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-tert-butyl-4-((2-(1H-indol-3-yl)ethyl)(((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)amino)-2-((tert-butoxycarbonyl) amino)butanoate(1373432-58-6)
• EPA Substance Registry System: (S)-tert-butyl-4-((2-(1H-indol-3-yl)ethyl)(((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)amino)-2-((tert-butoxycarbonyl) amino)butanoate(1373432-58-6)

Safety Data

• Hazardous Substances Data: 1373432-58-6(Hazardous Substances Data)

Upstream product

• 21950-36-7 5'-amino-5'-deoxy-2',3'-O-isopropylideneadenosine 

Relevant articles and documents

Development of rationally designed DNA N6 adenine methyltransferase inhibitors

A series of bisubstrate inhibitors for DNA N6 adenine methyltransferase (Dam) have been synthesized by linking an amine analogue of S-adenosylmethionine to an aryl moiety designed to probe the binding pocket of the DNA adenine base. An initial structure-activity relationship study has identified substituents that increase inhibitor potency to the ～10 μM range and improve selectivity against the human cytosine methyltransferase Dnmt1.