137344-86-6Relevant articles and documents
Ligand-Controlled Palladium-Catalyzed Carbonylation of Alkynols: Highly Selective Synthesis of α-Methylene-β-Lactones
Beller, Matthias,Ge, Yao,Jackstell, Ralf,Jiao, Haijun,Liu, Jiawang,Spannenberg, Anke,Yang, Ji,Ye, Fei
supporting information, p. 21585 - 21590 (2020/09/23)
The first general and regioselective Pd-catalyzed cyclocarbonylation to give α-methylene-β-lactones is reported. Key to the success for this process is the use of a specific sterically demanding phosphine ligand based on N-arylated imidazole (L11) in the presence of Pd(MeCN)2Cl2 as pre-catalyst. A variety of easily available alkynols provide under additive-free conditions the corresponding α-methylene-β-lactones in moderate to good yields with excellent regio- and diastereoselectivity. The applicability of this novel methodology is showcased by the direct carbonylation of biologically active molecules including natural products.
SUBSTITUTED ALKYNYL PYRIDINE COMPOUNDS AND METHODS OF USE
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Paragraph 0177, (2014/01/07)
The present invention provides novel substituted alkynyl pyridine compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.
Diacetone glucose architecture as a chirality template I. Crucial effects of the intramolecular oxygens upon the LiAlH4 reduction of the propargyl alcohol of 3-C-ethynyl-1,2:5,6-di-O-isopropylidene-α-D-allofuranose derivatives
Kakinuma, Katsumi,Matsuzawa, Toshihiro,Eguchi, Tadashi
, p. 6975 - 6982 (2007/10/02)
The facile as well as regio- and stereoselective reactivity of 3-C-ethynyl-1,2:5,6-di-O-isopropylidene-α-D-allofuranose derivatives for LiAlH4 reduction into the corresponding ethenyl derivatives were investigated. The effect of oxygen atoms on the reduction is discussed by means of semi-empirical MO calculation.
