1373497-00-7

Basic information

• Product Name: 2-(3-benzoylthioureido)-5-methyl-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxylic acid
• Synonyms: 2-(3-benzoylthioureido)-5-methyl-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxylic acid
• CAS NO: 1373497-00-7
• Molecular Weight: 376.457
• Mol File: 1373497-00-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(3-benzoylthioureido)-5-methyl-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-benzoylthioureido)-5-methyl-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxylic acid(1373497-00-7)
• EPA Substance Registry System: 2-(3-benzoylthioureido)-5-methyl-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxylic acid(1373497-00-7)

Safety Data

• Hazardous Substances Data: 1373497-00-7(Hazardous Substances Data)

Upstream product

• 1193-20-0 2-methyltetrahydro-4H-pyran-4-one 
• 1373497-02-9 tert-butyl 2-(3-benzoylthioureido)-5-methyl-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxylate 
• 1373497-01-8 tert-butyl 2-amino-5-methyl-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxylate 
• 532-55-8 Benzoyl isothiocyanate 

Relevant articles and documents

Rab7 GTPase inhibitors and related methods of treatment

This invention relates to compounds and their use as inhibitors or activators of Rab7 GTPase to treat or prevent the onset of Rab 7 GTPase-associated disorders such as neuropathies, cancer, metabolic diseases of bone and lipid storage. The invention is also applicable to infectious diseases where Rab7 is inactivated or its protein-protein interactions are modulated to facilitate intracellular survival of pathogens. The compound described acts as a competitive inhibitor of nucleotide binding and as such also has utility as a scaffold for targeting other small GTPases. In one aspect, methods of treatment of the invention are used to treat or prevent the onset of hereditary sensory neuropathies such as Charcot-Marie-Tooth type 2B disease. Related pharmaceutical compositions, assays, and drug screens are also provided.