137372-39-5

Basic information

• Product Name: L-Proline, N-[(1,1-dimethylethoxy)carbonyl]glycyl-L-phenylalanyl-, phenylmethyl ester
• CAS NO: 137372-39-5
• Molecular Formula: C28H35N3O6
• Molecular Weight: 509.602
• Mol File: 137372-39-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: L-Proline, N-[(1,1-dimethylethoxy)carbonyl]glycyl-L-phenylalanyl-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Proline, N-[(1,1-dimethylethoxy)carbonyl]glycyl-L-phenylalanyl-, phenylmethyl ester(137372-39-5)
• EPA Substance Registry System: L-Proline, N-[(1,1-dimethylethoxy)carbonyl]glycyl-L-phenylalanyl-, phenylmethyl ester(137372-39-5)

Safety Data

• Hazardous Substances Data: 137372-39-5(Hazardous Substances Data)

Upstream product

• 70462-58-7 benzyl (tert-butoxycarbonyl)-L-phenylalanyl-L-prolinate 
• 16652-71-4 benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 4530-20-5 BOC-glycine 
• 87297-14-1 (S)-1-((S)-2-((benzyloxy)carbonyl)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-aminium chloride 

Downstream Products

• 397244-46-1 Boc-Gly-Gly-Phe-Pro-OBzl 
• 76046-35-0 Boc-Gly-Gly-Phe-Pro-OH 

Relevant articles and documents

Hydrophobicity Dependence of Oxidation of Tetrapeptides of Elastin Sequences with Mn(III): Synthesis, Characterization, Kinetics, and Mechanistic Study

The analogues of elastin sequences, glycyl-glycyl-alanyl-proline (GGAP), glycyl-glycyl-phenylalanyl-proline (GGFP), and glycyl-glycyl-isoleucyl-proline (GGIP) were synthesized by classical solution phase method and characterized. The kinetics of oxidation of these tetrapeptides (TETP) by Mn(III) has been studied in the presence of sulphate ions in acidic solution at 25 deg C. The reaction was followed spectrophotometrically at λmax = 500 nm. A first-order dependence of rate on both [Mn(III)] and [TETP] was observed. The rate is independent of the concentration of the reduction product, Mn(II), and hydrogen ions. The effects of varying the dielectric constant of the medium and addition of anions such as sulphate, chloride, or perchlorate were studied. Activation parameters have been evaluated using Arrhenius and Eyring plots. The oxidation products were isolated and characterized. A mechanism involving the reaction of TETP with Mn(III) in the rate-limiting step is suggested. An apparent correlation was noted between the rate of oxidation and the hydrophobicity of these sequences, where increased hydrophobicity results in increased rate of oxidation.