137382-32-2

Basic information

• Product Name: (2-carboxyphenyl)-(pyridin-3-yl)-ketone
• Synonyms: (2-carboxyphenyl)-(pyridin-3-yl)-ketone
• CAS NO: 137382-32-2
• Molecular Weight: 227.219
• Mol File: 137382-32-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (2-carboxyphenyl)-(pyridin-3-yl)-ketone(CAS DataBase Reference)
• NIST Chemistry Reference: (2-carboxyphenyl)-(pyridin-3-yl)-ketone(137382-32-2)
• EPA Substance Registry System: (2-carboxyphenyl)-(pyridin-3-yl)-ketone(137382-32-2)

Safety Data

• Hazardous Substances Data: 137382-32-2(Hazardous Substances Data)

Upstream product

• 626-55-1 3-Bromopyridine 
• 85-44-9 phthalic anhydride 
• 88-65-3 2-bromobenzoic-acid 

Downstream Products

• 222529-60-4 6-benzyloxy-2,3-bis(hydroxymethyl)-7-methoxy-1-<2-<1(2H)-phthalazinon-4-(3-pyridyl)-2-yl>-4-pyridyl>-naphthalene 
• 1372156-06-3 C₂₉H₃₁N₅O₂ 
• 137381-31-8 2-(2-Imidazol-1-yl-ethyl)-4-pyridin-3-yl-2H-phthalazin-1-one 
• 137381-98-7 4-(1-Oxo-4-pyridin-3-yl-1H-phthalazin-2-ylmethyl)-benzoic acid methyl ester 
• 137381-66-9 2-ethyl-4-(3-pyridyl)-1(2H)-phthalazinone 
• 221456-43-5 4-{4-[2-(pyridine-3-carbonyl)-benzoyl]-piperazine-1-carbonyl}-2-pyridin-3-yl-thiazolidine-3-carboxylic acid tert-butyl ester 
• 221456-42-4 piperazin-1-yl-[2-(pyridine-3-carbonyl)-phenyl]-methanone 
• 46492-08-4 benz[g]isoquinoline-5,10-dione 

Relevant articles and documents

Metallation of pyridines and quinolines in the presence of a remote carboxylate group. New syntheses of heterocyclic quinones

2-(3- and 2-Pyridylcarbonyl)benzoic acids (2,3), 2-(2-pyridylcarbonyl) thiophene-3-carboxylic acid (6), 2-(3-quinolylcarbonyl)benzoic acid (10), and most of the corresponding esters (compounds 1, 7 and 9) are readily synthesized and involved in a deprotonation-condensation sequence. Biologically active aza-anthraquinones such as benzo[g]isoquinoline-5,10-dione (2-azaanthraquinone, 4) and benzo[g]quinoline- 5,10-dione (1-azaanthraquinone, 5) are prepared using the strategy. Extension to other heterocyclic quinones such as thieno[3,2-g]quinoline-4,9-dione (8) and benzo[j]phenanthridine-7,12-dione (11) is also investigated.

4-heteroaryl phthalazin-1(2H)-one derivatives as potent melanin concentrating hormone receptor 1 (MCH-R1) antagonists

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Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. 1. 2-[2-(1-imidazolyl)alkyl]- 1(2H)-phthalazinones

A number of 4-substituted 2-[ω-(1-imidazolyl)alkyl]-1(2H)-phthalazinones were synthesized in order to develop agents possessing both thromboxane A2 synthetase inhibitory and bronchodilatory activities. The pharmacological evaluation of these compounds disclosed that they have both activities to various extents. Both activities were slightly dependent on the length of the 2-substituents and largely affected by the nature of the 4-substituents. Compounds bearing phenyl and thienyl groups exhibited relatively high and well-rounded activities. Among these compounds, 12j and 15f were found to be the most effective agents having well-rounded activities in vitro and in vivo. Introduction of a carboxyl group reduced both activities contrary to our expectation. 4-(3-Pyridyl)phthalazinone 18b was of particular interest because of unexpectedly high in vivo activities in spite of an absence of significant in vitro activities.