1374006-38-8

Basic information

• Product Name: C₁₈H₁₉N₃O₄
• CAS NO: 1374006-38-8
• Molecular Weight: 341.367
• Mol File: 1374006-38-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₈H₁₉N₃O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₁₉N₃O₄(1374006-38-8)
• EPA Substance Registry System: C₁₈H₁₉N₃O₄(1374006-38-8)

Safety Data

• Hazardous Substances Data: 1374006-38-8(Hazardous Substances Data)

Upstream product

• 99-55-8 2-methyl-5-nitroaniline 
• 5434-30-0 N-(5-amino-2-methylphenyl)acetamide 
• 100275-94-3 6-isocyanato-2,3-dihydrobenzo[b][1,4]dioxine 

Relevant articles and documents

New diarylureas and diarylamides possessing acet(benz)amidophenyl scaffold: Design, synthesis, and antiproliferative activity against melanoma cell line

A series of new diarylurea and diarylamide derivatives possessing acet(benz)amidophenyl scaffold was synthesized. Their in vitro antiproliferative activity was tested against A375P human melanoma cell line. Compounds 1c,d and 2c,d showed the highest potencies with IC50 values in sub-micromolar scale. In addition, compounds 1b,e,l and 2e,l were more potent than Sorafenib but with IC50 values in micromolar range. Moreover, compound 2c was equipotent to Vemurafenib, and 2d showed higher potency than Vemurafenib against A375P. Molar refractometry calculation and ADME profiling of the highest potent four derivatives 1c,d and 2c,d are also reported.