137419-24-0

Basic information

• Product Name: CHEMBRDG-BB 4011973
• Synonyms: CHEMBRDG-BB 4011973;TERT-BUTYL 1'H-SPIRO[INDENE-1,4'-PIPERIDINE]-1'-CARBOXYLATE;tert-Butyl spiro[1H-indene-1,4'-piperidine]-1'-carboxylate;tert-butyl spiro[indene-1,4'-piperidine]-1'-carboxylate;tert-butyl 1'H-spiro[indene-1,4'-piperidine]-1'-carboxylate(SALTDATA: FREE);1'-BOC-SPIRO(INDENE-1,4'-PIPERIDINE);Spiro[1H-indene-1,4'-piperidine]-1'-carboxylic acid 1,1-diMethyl ethyl ester;1'-(tert-butyloxycarbonyl)spiro
• CAS NO: 137419-24-0
• Molecular Formula: C₁₈H₂₃NO₂
• Molecular Weight: 285.38
• Mol File: 137419-24-0.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 406.2±45.0 °C(Predicted)
• Appearance: /
• Density: 1.13±0.1 g/cm3(Predicted)
• PKA: -0.79±0.20(Predicted)
• CAS DataBase Reference: CHEMBRDG-BB 4011973(CAS DataBase Reference)
• NIST Chemistry Reference: CHEMBRDG-BB 4011973(137419-24-0)
• EPA Substance Registry System: CHEMBRDG-BB 4011973(137419-24-0)

Safety Data

• Hazardous Substances Data: 137419-24-0(Hazardous Substances Data)

Usage

General Description

CHEMBRDG-BB 4011973 is a chemical compound with the molecular formula C20H27N3O3S. It is a member of the benzoylphenylurea class of chemicals and is commonly used as an insecticide and acaricide. It functions by disrupting the growth and development of insect and mite pests, making it a valuable tool in agricultural pest control. The compound is believed to work by inhibiting chitin synthesis in the insects, leading to disruption in their exoskeleton formation and ultimately causing their death. Due to its effectiveness in pest control, CHEMBRDG-BB 4011973 is widely used in agricultural settings to protect crops from damage caused by insects and mites.

Upstream product

• 118753-70-1 N-(tert-butyloxycarbonyl)bis(2-chloroethyl)amine 
• 95-13-6 1-indene 
• 4039-32-1 lithium hexamethyldisilazane 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 159634-59-0 2,3-dihydro-3-oxo-spiro[1H-indene-1,4'-piperidine]-1'-carboxylic acid 1,1-dimethylethyl ester 
• 241819-85-2 tert-butyl 2-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate 
• 185525-42-2 tert-butyl 3-hydroxy-2,3-dihydrospiro[indene-1,4’-piperidine]-1‘-carboxylate 
• 189149-23-3 tert-butyl 2-hydroxy-2,3-dihydrospiro[indene-1,4’-piperidine]-1‘-carboxylate 
• 209128-15-4 1'-(tert-butoxycarbonyl)spiro[indene-1,4'-piperidine]-3-carboxylic acid 

Relevant articles and documents

Discovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2

A series of spiropiperidine carbazoles were synthesized and evaluated as MCHR2 antagonists using a FLIPR assay. The pharmacokinetic properties of selected compounds have also been studied. This effort led to the discovery of potent and specific MCHR2 antagonists. Compound 38 demonstrated good pharmacokinetic properties across rat, beagle dog and rhesus monkey and had a favorable selectivity profile against a number of other receptors. These MCHR2 antagonists are considered appropriate tool compounds for study of the function of MCHR2 in vivo.

Novel heterocyclic derivative capable of being used as SHP2 inhibitor

The invention relates to a novel heterocyclic derivative capable of being used as an SHP2 inhibitor, specifically relates to a compound shown by a formula I or pharmaceutically acceptable salts thereof, further relates to a use of the compound shown by the formula I or the pharmaceutically acceptable salts thereof and a pharmaceutical composition thereof in drug preparation, and particularly relates to a use in preparation of drugs for treatment, inhibition or prevention of diseases or discomforts mediated by SHP2 activity.

Compound as potassium channel modulator

The invention relates to a compound as a potassium channel modulator, which is a compound of a formula (I) or a pharmaceutically acceptable salt thereof. The compound or the pharmaceutically acceptable salt thereof is effective for curing and preventing diseases and symptoms influenced by the activity of potassium ion channels.