1374348-10-3

Basic information

• Product Name: 2-((4-chlorophenyl)ethynyl)-5-phenyl-1,3,4-oxadiazole
• Synonyms: 2-((4-chlorophenyl)ethynyl)-5-phenyl-1,3,4-oxadiazole
• CAS NO: 1374348-10-3
• Molecular Weight: 280.713
• Mol File: 1374348-10-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-((4-chlorophenyl)ethynyl)-5-phenyl-1,3,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((4-chlorophenyl)ethynyl)-5-phenyl-1,3,4-oxadiazole(1374348-10-3)
• EPA Substance Registry System: 2-((4-chlorophenyl)ethynyl)-5-phenyl-1,3,4-oxadiazole(1374348-10-3)

Safety Data

• Hazardous Substances Data: 1374348-10-3(Hazardous Substances Data)

Upstream product

• 825-56-9 2-phenyl-1,3,4-oxadiazole 
• 3240-10-6 (4-chlorophenyl)propiolic acid 
• 873-73-4 4-n-chlorophenylacetylene 
• 51039-53-3 2-phenyl-5-bromo-1,3,4-oxadiazole 
• 613-94-5 benzoic acid hydrazide 
• 104-88-1 4-chlorobenzaldehyde 
• 77295-59-1 1-chloro-4-(2,2-dibromovinyl)benzene 

Relevant articles and documents

Palladium-Catalyzed Decarboxylative Cross-Coupling of 1,3,4-Oxa-diazoles with Alkynoic Acids: A Simple Route for the Preparation of 2-Alkynylated 1,3,4-Oxadiazoles

For the first time 2-alk-1-ynyl-5-(het)aryl-1,3,4-oxadiazole derivatives have been synthesized by the decarboxylative cross-coupling of alk-2-ynoic acids with 2-(het)aryl-1,3,4-oxadiazoles, employing palladium(II) chloride as the catalyst and silver(I) oxide as an oxidant with 1,3-bis(diphenylphosphanyl)propane as a ligand. Products were formed in high yields with no byproduct.

Copper-mediated C-H activation of 1,3,4-oxadiazoles with 1,1-dibromo-1-alkenes using PEG-400 as a solvent medium: Distinct approach for the alkynylation of 1,3,4-oxadiazoles

The direct C-H alkynylation of 1,3,4-oxadiazoles with 1,1-dibromo-1-alkenes has been accomplished by using a combination of CuBr/LiOtBu in PEG-400 (a green solvent) at 80 °C. The products were formed in high yields (73-86%) in 2 h. No additional ligand or volatile solvent was required and the conversion was ecofriendly. The direct C-H alkynylation of 1,3,4-oxadiazoles with 1,1-dibromo-1-alkenes has been accomplished by using a combination of CuBr/LiOtBu in PEG-400 (a green solvent) at 80 °C. The products were formed in high yields (73-86%) in 2 h. No additional ligand or volatile solvent was required and the conversion was ecofriendly. Copyright