1374353-46-4

Basic information

• Product Name: 5-bromo-3-(pyridin-4-yl)-1-trityl-1H-indazole
• Synonyms: 5-bromo-3-(pyridin-4-yl)-1-trityl-1H-indazole
• CAS NO: 1374353-46-4
• Molecular Weight: 516.44
• Mol File: 1374353-46-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-bromo-3-(pyridin-4-yl)-1-trityl-1H-indazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-3-(pyridin-4-yl)-1-trityl-1H-indazole(1374353-46-4)
• EPA Substance Registry System: 5-bromo-3-(pyridin-4-yl)-1-trityl-1H-indazole(1374353-46-4)

Safety Data

• Hazardous Substances Data: 1374353-46-4(Hazardous Substances Data)

Upstream product

• 53857-57-1 5-bromo-1H-indazole 
• 459133-66-5 5-bromo-3-iodo-1H-indazole 
• 76-83-5 trityl chloride 
• 1692-15-5 4-pyridylboronic acid 

Downstream Products

• 1374353-24-8 tert-butyl 3-(4-(3-(pyridin-4-yl)-1-trityI-1H-indazol-5-yl)-1H-pyrazoI-1-yl)piperidine-1-carboxylate 
• 1374353-23-7 3-(pyridin-4-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-trityl-1H-indazole 

Relevant articles and documents

Discovery of G2019S-Selective Leucine Rich Repeat Protein Kinase 2 inhibitors with in vivo efficacy

Mutations in the Leucine Rich Repeat Protein Kinase 2 gene (LRRK2) are the most common genetic causes of Parkinson's Disease (PD). The G2019S mutation is the most common inherited LRRK2 mutation, occurs in the kinase domain, and results in increased kinase activity. We report the discovery and development of compound 38, an indazole-based, G2019S-selective (>2000-fold vs. WT) LRRK2 inhibitor capable of entering rodent brain (Kp = 0.5) and selectively inhibiting G2019S-LRRK2. The compounds disclosed herein present a starting point for further development of brain penetrant G2019S selective inhibitors that hopefully reduce lung phenotype side-effects and pave the way to providing a precision medicine for people with PD who carry the G2019S mutation.