1374408-56-6

Basic information

• Product Name: (6,6'-ditrifluoromethoxybiphenyl-2,2'-diyl)bis(diphenylphosphine oxide)
• CAS NO: 1374408-56-6
• Molecular Weight: 722.56
• Mol File: 1374408-56-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (6,6'-ditrifluoromethoxybiphenyl-2,2'-diyl)bis(diphenylphosphine oxide)(CAS DataBase Reference)
• NIST Chemistry Reference: (6,6'-ditrifluoromethoxybiphenyl-2,2'-diyl)bis(diphenylphosphine oxide)(1374408-56-6)
• EPA Substance Registry System: (6,6'-ditrifluoromethoxybiphenyl-2,2'-diyl)bis(diphenylphosphine oxide)(1374408-56-6)

Safety Data

• Hazardous Substances Data: 1374408-56-6(Hazardous Substances Data)

Upstream product

• 1079-66-9 chloro-diphenylphosphine 
• 2252-44-0 1-bromo-3-(trifluoromethoxy)benzene 
• 1374408-55-5 diphenyl (3-(trifluoromethoxy)phenyl)phosphine oxide 

Relevant articles and documents

A new electronically deficient atropisomeric diphosphine ligand (S)-CF 3O-BiPhep and its application in asymmetric hydrogenation

A new electronically deficient atropisomeric diphosphine ligand (S)-CF 3O-BiPhep was synthesized from 1-bromo-3-(trifluoromethoxy)benzene in high yield. The key steps included oxidative coupling with anhydrous ferric chloride and optical resolution by (+)-DMTA. The ligand afforded high performance for Ir-catalyzed asymmetric hydrogenation of quinolines with ee up to 92% and TON up to 25,000. It was also successfully applied to the Pd-catalyzed asymmetric hydrogenation of simple indoles with ee up to 87% and Rh-catalyzed asymmetric 1,4-addition of phenylboronic acid to 2-cyclohexenone with 97% ee.