1374765-29-3

Basic information

• Product Name: 2-phenyl-4-(adamantane-2'-spiro)-oxazolin-5-one
• Synonyms: 2-phenyl-4-(adamantane-2'-spiro)-oxazolin-5-one
• CAS NO: 1374765-29-3
• Molecular Weight: 281.354
• Mol File: 1374765-29-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-phenyl-4-(adamantane-2'-spiro)-oxazolin-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-4-(adamantane-2'-spiro)-oxazolin-5-one(1374765-29-3)
• EPA Substance Registry System: 2-phenyl-4-(adamantane-2'-spiro)-oxazolin-5-one(1374765-29-3)

Safety Data

• Hazardous Substances Data: 1374765-29-3(Hazardous Substances Data)

Upstream product

• 70887-49-9 2-Hydroxy-2-ethynyladamantane 
• 1374765-28-2 2-phenyl-4-(adamantane-2'-spiro)-5-methylidene-oxazoline 
• 1374765-27-1 2-ethynyl-2-benzamidoadamantane 
• 700-58-3 2-Adamantanone 

Downstream Products

• 111697-04-2 2-benzamidoadamantane-2-carboxylic acid 
• 1374765-50-0 (R)-N^α-[(2-benzoylamino-adamantan-2-yl)carbonyl]alanine 
• 1374765-48-6 (Nα-[(2-benzoylamino-adamantan-2-yl)carbonyl]-(S)-alanyl)-glycine 
• 1374765-36-2 N-[(2-benzoylamino-adamantan-2-yl)carbonyl]-2-(imidazol-4-yl)-ethylamine 
• 1374765-39-5 (R,R)-N¹-[(2-benzoylamino-adamantan-2-yl)carbonyl]-1,2-diphenylethylenediamine 
• 1374765-41-9 (S)-Nα-[(2-benzoylamino-adamantan-2-yl)carbonyl]-phenylalanine methyl ester 
• 1374765-44-2 (S)-N-[(2-benzoylamino-adamantan-2-yl)carbonyl]-1-tert-butyl-2-hydroxy-ethylamine 
• 1374765-42-0 (S)-Nα-[(2-benzoylamino-adamantan-2-yl)carbonyl]-phenylalanine 
• 1374765-34-0 N-[(2-benzoylamino-adamantan-2-yl)carbonyl]-2-phenyl-ethylamine 
• 1374765-46-4 bs[(2-benzoylamino-adamantan-2-yl)carbonyl]-ethylenediamine 
• 1374765-51-1 N₁-[(2-benzoylamino-adamantan-2-yl)carbonyl]-ethylenediamine 
• 1374765-38-4 N-[(2-benzoylamino-adamantan-2-yl)carbonyl]-cyclopropylamine 
• 1374765-32-8 N-[(2-benzoylamino-adamantan-2-yl)carbonyl]-benzylamine 

Relevant articles and documents

Flow synthesis and biological studies of an analgesic adamantane derivative that inhibits P2X7-evoked glutamate release

We report the biological evaluation of a class of adamantane derivatives, which were achieved via modified telescoped machine-assisted flow procedure. Among the series of compounds tested in this work, 5 demonstrated outstanding analgesic properties. This compound showed that its action was not mediated through direct interaction with opioid and/or cannabinoid receptors. Moreover, it did not display any significant anti-inflammatory properties. Experiments carried out on rat cerebrocortical purified synaptosomes indicated that 5 inhibits the P2X7-evoked glutamate release, which may contribute to its antinociceptive properties. Nevertheless, further experiments are ongoing to characterize the pharmacological properties and mechanism of action of this molecule.