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A he rosuvastain sandbank amino acid salt and its preparation method and application
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Paragraph 0126-0135, (2017/01/31)
The invention relates to a rosuvastatin amino acid salt as well as a preparation method of the rosuvastatin amino acid salt. Such a compound, namely, amino acid salt, is prepared through the reaction between rosuvastatin acid and basic amino acid. The preparation method comprises the following steps of: (1) weighing rosuvastatin acid, and dissolving into C1-C6 alcohol solvents, water or a halohydrocarbon solution to obtain a solution A; (2) weighing basic amino acid, and dissolving into C1-C6 alcohol solvents or water to obtain a solution B; (3) adding the solution B to the solution A, stirring and remaining overnight, cooling the reaction liquid to reach room temperature, and then vaporizing and eliminating the solvents; (4) adding methanol, separating and filtering to remove excessive basic amino acid; and (5) concentrating, refluxing, cooling, filtering and drying to obtain the amino acid salt of the rosuvastatin. The rosuvastatin amino acid salt prepared by the preparation method not only has the effect of treating high cholesterol blood lipid and combined hyperlipidemia, and also gains the function of amino acid, thus the salt effectively fills in gaps due to the known side effects of hurt of calcium salt, sylvite and sodium salt and the like to the liver.