1374979-30-2

Basic information

• Product Name: C₁₅H₁₈BrN₃O₂
• CAS NO: 1374979-30-2
• Molecular Weight: 352.231
• Mol File: 1374979-30-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₅H₁₈BrN₃O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₁₈BrN₃O₂(1374979-30-2)
• EPA Substance Registry System: C₁₅H₁₈BrN₃O₂(1374979-30-2)

Safety Data

• Hazardous Substances Data: 1374979-30-2(Hazardous Substances Data)

Upstream product

• 606-45-1 2-methoxybenzoic acid methyl ester 
• 35276-83-6 3-(2-methoxyphenyl)-3-oxopropanenitrile 
• 4509-90-4 5-bromovaleroyl chloride 
• 149246-82-2 5-(2-methoxyphenyl)-2H-pyrazol-3-ylamine 

Relevant articles and documents

Discovery of a novel alpha-7 nicotinic acetylcholine receptor agonist series and characterization of the potent, selective, and orally efficacious agonist 5-(4-acetyl[1,4]diazepan-1-yl)pentanoic acid [5-(4-methoxyphenyl)-1H- pyrazol-3-yl] amide (SEN15924, WAY-361789)

Alpha-7 nicotinic acetylcholine receptors (α7 nAChR) are implicated in the modulation of many cognitive functions such as attention, working memory, and episodic memory. For this reason, α7 nAChR agonists represent promising therapeutic candidates for the treatment of cognitive impairment associated with Alzheimer's disease (AD) and schizophrenia. A medicinal chemistry effort, around our previously reported chemical series, permitted the discovery of a novel class of α7 nAChR agonists with improved selectivity, in particular against the α3 receptor subtype and better ADME profile. The exploration of this series led to the identification of 5-(4-acetyl[1,4] diazepan-1-yl)pentanoic acid [5-(4-methoxyphenyl)-1H-pyrazol-3-yl] amide (25, SEN15924, WAY-361789), a novel, full agonist of the α7 nAChR that was evaluated in vitro and in vivo. Compound 25 proved to be potent and selective, and it demonstrated a fair pharmacokinetic profile accompanied by efficacy in rodent behavioral cognition models (novel object recognition and auditory sensory gating).