1375100-69-8Relevant articles and documents
Synthesis and antitumor and antibacterial evaluation of fluoro-quinolone derivatives (III): Mono- and bis-Schiff-bases
Hu, Guo Qiang,Wu, Xiao Kui,Wang, Guo Qiang,Duan, Nan Nan,Wen, Xiao Yi,Cao, Tie Yao,Jun, Yin,Wei, Wang,Xie, Song Qiang,Huang, Wen Long
, p. 515 - 517 (2012/08/13)
To further explore an efficient modified route for the shift from an antibacterial fluoroquinolone to an antitumor one, mono-Schiff bases 6a-6h related to ciprofloxacin C3 carbonylhydrazone and bis-Schiff bases 4a-4h corresponding to C3/C7 carbonylhydrazone/hydrazone attached on a skeleton of ciprofloquinolone were designed and synthesized, and their in vitro antitumor activity against CHO, HL60, L1210 cells and antibacterial activity against Staphylococcus aureus and Escherichia coli were also reported.