137522-47-5

Basic information

• Product Name: 3-Pyridinecarboxylicacid,6-amino-5-cyano-2-methyl-,ethylester(9CI)
• Synonyms: 3-Pyridinecarboxylicacid,6-amino-5-cyano-2-methyl-,ethylester(9CI);ethyl 6-amino-5-cyano-2-methylnicotinate
• CAS NO: 137522-47-5
• Molecular Formula: C₁₀H₁₁N₃O₂
• Molecular Weight: 205.21
• Product Categories: AMINOACID
• Mol File: 137522-47-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 377.8°Cat760mmHg
• Flash Point: 182.3°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 6.59E-06mmHg at 25°C
• CAS DataBase Reference: 3-Pyridinecarboxylicacid,6-amino-5-cyano-2-methyl-,ethylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarboxylicacid,6-amino-5-cyano-2-methyl-,ethylester(9CI)(137522-47-5)
• EPA Substance Registry System: 3-Pyridinecarboxylicacid,6-amino-5-cyano-2-methyl-,ethylester(9CI)(137522-47-5)

Safety Data

• Hazardous Substances Data: 137522-47-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H11N3O2/c1-3-15-10(14)8-4-7(5-11)9(12)13-6(8)2/h4H,3H2,1-2H3,(H2,12,13)/p+1

Upstream product

• 137522-48-6 6-(benzylamino)-5-cyano-2-methylnicotinic acid ethyl ester 
• 626-34-6 ethyl aminocrotonate 
• 123-06-8 Ethoxymethylenemalononitrile 
• 52600-52-9 5-Cyano-2-methyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid ethyl ester 
• 64119-42-2 ethyl 6-chloro-5-cyano-2-methylnicotinate 

Downstream Products

• 64119-42-2 ethyl 6-chloro-5-cyano-2-methylnicotinate 
• 137664-20-1 Sodium; 6-amino-5-carbamoyl-2-methyl-nicotinate 
• 100524-09-2 2-amino-6-methylnicotinamide 
• 137522-54-4 amide of 2-amino-5-carboxy-6-methylnicotinic acid 

Relevant articles and documents

Molecular modelling, synthesis and acetylcholinesterase inhibition of ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate

In silico analysis of ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate (2) predicts that this molecule should be successfully docked in the PAS, and easily accommodated in the CAS of AChE. The synthesis and the AChE/BuChE inhibition studies are reported, confirming that compound 2 is a potent and selective AChE inhibitor, and consequently, a new lead compound for further development into new dual CAS/PAS cholinergic agents for the treatment of Alzheimer's disease.

Synthesis of condensed heterocycles on the basis of 2-chloro-3-cyanopyridine

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