13754-45-5

Basic information

• Product Name: 1-(2-CHLORO-BENZOYL)-PIPERAZINE
• Synonyms: AKOS BB-6375;1-(2-CHLORO-BENZOYL)-PIPERAZINE;(2-CHLORO-PHENYL)-PIPERAZIN-1-YL-METHANONE;BUTTPARK 145\16-04;1-(2-CHLORO-BENZOYL)-PIPERAZINE >98%
• CAS NO: 13754-45-5
• Molecular Formula: C₁₁H₁₃ClN₂O
• Molecular Weight: 224.69
• Product Categories: Piperaizine;piperazines
• Mol File: 13754-45-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 195 °C
• Boiling Point: 383.8 °C at 760 mmHg
• Flash Point: 185.9 °C
• Appearance: /
• Density: 1.231 g/cm³
• Vapor Pressure: 4.3E-06mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: 2-8°C
• PKA: 8.44±0.10(Predicted)
• CAS DataBase Reference: 1-(2-CHLORO-BENZOYL)-PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-CHLORO-BENZOYL)-PIPERAZINE(13754-45-5)
• EPA Substance Registry System: 1-(2-CHLORO-BENZOYL)-PIPERAZINE(13754-45-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26
• Hazardous Substances Data: 13754-45-5(Hazardous Substances Data)

Usage

General Description

1-(2-chloro-benzoyl)-piperazine is a chemical compound that belongs to the class of piperazine derivatives. It is characterized by a piperazine ring structure with a 2-chloro-benzoyl group attached to it. 1-(2-CHLORO-BENZOYL)-PIPERAZINE is commonly used in the pharmaceutical industry as an intermediate in the synthesis of various drugs, including antipsychotics, antidepressants, and antihistamines. It has also been studied for its potential anti-cancer and anti-inflammatory properties. Additionally, 1-(2-chloro-benzoyl)-piperazine has been found to have sedative and anti-anxiety effects, making it a potentially useful compound for the treatment of psychiatric disorders. However, further research is needed to fully understand its pharmacological and therapeutic potential.

InChI:InChI=1/C11H13ClN2O/c12-10-4-2-1-3-9(10)11(15)14-7-5-13-6-8-14/h1-4,13H,5-8H2

Upstream product

• 609-65-4 o-chlorobenzoyl chloride 
• 118-91-2 ortho-chlorobenzoic acid 
• 110-85-0 piperazine 
• 142-64-3 piperazine dihydrochloride 

Downstream Products

• 1228934-35-7 1-{4-[3-{4-(2-chlorobenzoyl)piperazin-1-yl}propoxy]phenyl}ethanone 
• 1228934-37-9 1-{2-[3-{4-(2-chlorobenzoyl)piperazin-1-yl}propoxy]phenyl}ethanone 
• 1373134-07-6 1-(3-[3-{4-(2-chlorobenzoyl)piperazin-1-yl}propoxy]phenyl)ethanone 
• 1373134-05-4 3-[3-{4-(2-chlorobenzoyl)piperazin-1-yl}propoxy]benzaldehyde 
• 1226894-87-6 C₂₇H₃₁ClF₃N₅O₃ 
• 892495-26-0 2-[4-(2-chlorobenzoyl)-1-piperazinomethyl]-3,5,6-trimethylpyrazine 
• 1075248-09-7 C₂₁H₁₇ClN₂O₄ 
• 1075248-23-5 C₂₁H₁₉ClN₂O₃ 

Relevant articles and documents

Looking toward the Rim of the Active Site Cavity of Druggable Human Carbonic Anhydrase Isoforms

We report the synthesis and biochemical evaluation of a series of substituted 4-(4-aroylpiperazine-1-carbonyl)benzenesulfonamides (5a-s) developed as inhibitors of druggable carbonic anhydrase (CA) isoforms, as tools for the identification of new therapeu

Expanding the structural diversity of Bcr-Abl inhibitors: Hybrid molecules based on GNF-2 and Imatinib

In order to expand the structural diversity of Bcr-Abl inhibitors, twenty hybrids (series E and P) have been synthesized and characterized based on Imatinib and GNF-2. Their biological activities were evaluated in vitro against human leukemia cells. Most compounds exhibited potent antiproliferative activity against K562 cells, especially for compounds E4, E5 and E7. Furthermore, these new hybrids were also screened for Abl kinase inhibitory activity, and some of them inhibited Abl kinase with low micromolar IC50 values. In particular, compound P3 displayed the most potent activity with IC50 value of 0.017 μM comparable with that of Imatinib. Molecular docking studies indicated that these novel hybrids fitted well with the active site of Bcr-Abl. These results suggested the great potential of these compounds as novel Bcr-Abl inhibitors.

Synthesis and evaluation of meta substituted 1-(aryloxypropyl)-4- (chloroaryl) piperazines as potential atypical antipsychotics

A series of 1-(aryloxypropyl)-4-(chloroaryl) piperazines have been synthesized based upon their physicochemical similarity with respect to standard atypical antipsychotic drugs and their potential to cross the blood-brain barrier (log BB) as calculated by