1375469-38-7

Basic information

• Product Name: BAY-1082439
• Synonyms: BAY-1082439;BAY 2439;N-[8-[[(2R)-2-Hydroxy-3-(morpholin-4-yl)propyl]oxy]-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]-2-methylpyridine-3-carboxamide;(R)-N-(8-(2-hydroxy-3-morpholinopropoxy)-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)-2-methylnicotinamide
• CAS NO: 1375469-38-7
• Molecular Formula: C25H30N6O5
• Molecular Weight: 494.5429
• Mol File: 1375469-38-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BAY-1082439(CAS DataBase Reference)
• NIST Chemistry Reference: BAY-1082439(1375469-38-7)
• EPA Substance Registry System: BAY-1082439(1375469-38-7)

Safety Data

• Hazardous Substances Data: 1375469-38-7(Hazardous Substances Data)

Usage

General Description

BAY-1082439 is a novel small molecule inhibitor of phosphoinositide 3-kinase (PI3K) delta and gamma isoforms, which are enzymes that play a crucial role in various cellular processes such as cell growth, proliferation, and survival. BAY-1082439 has shown promising potential as a therapeutic agent for the treatment of various cancers and inflammatory diseases. BAY-1082439 has been found to demonstrate potent and selective inhibition of PI3K delta and gamma, and has shown favorable pharmacokinetic properties and tolerability in preclinical studies. Its ability to specifically target these key enzymes makes it a promising candidate for the development of new cancer and anti-inflammatory therapies.

Upstream product

• 65719-09-7 methyl 2-methylnicotinate 
• 3222-56-8 2-methylnicotinic acid 
• 1721-26-2 ethyl 2-methyl nicotinate 
• 1375468-81-7 4-{[(4R)-2-oxido-1,3,2-dioxathiolan-4-yl]methyl}morpholine hydrochloride 
• 222021-47-8 (2R)-3-(morpholin-4-yl)propane-1,2-diol 
• 1032570-69-6 8-(benzyloxy)-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine 
• 887202-50-8 3-(benzyloxy)-6-(4,5-dihydro-1H-imidazol-2-yl)-2-methoxyaniline 
• 2450-27-3 4-(benzyloxy)-3-methoxy-2-nitrobenzaldehyde 
• 2450-26-2 2-nitrovanillin 
• 2698-69-3 4-formyl-2-methoxy-3-nitrophenyl acetate 
• 881-68-5 vanillin acetate 
• 110-91-8 morpholine 

Relevant articles and documents

2-methyl nicotinate as well as preparation method and application thereof

The invention relates to 2-methyl nicotinate as well as a preparation method and application thereof. The preparation method comprises the following steps: (1) reacting 1, 1, 3, 3-tetramethoxypropane or 1, 1, 3, 3-tetraethoxypropane under the action of acid to obtain a compound B; (2) reacting the compound B and beta-aminocrotonate in a first organic solvent to obtain 2-methyl nicotinate, wherein no foul acrolein is used in the process, the safety coefficient of production is effectively improved, the reaction raw materials are easy to obtain, the conditions are mild, the operation is simple, the yield is greater than 65%, the product purity reaches 98% or above, and the method is suitable for industrial production and has a wide application prospect. The obtained product can be used as an intermediate for synthesizing 2-methyl nicotinic acid, and can be used for synthesizing medicines.

SYNTHESIS OF PI3K INHIBITOR AND SALTS THEREOF

The present invention relates to a novel method of preparing a compound of formula (I) or salt thereof, to novel intermediate compounds, to the use of said novel intermediate compounds for the preparation of said compound of formula (I) or salt thereof. T