137553-42-5 Usage
Description
2-Fluoro-4-iodo benzonitrile, also known as 2-FLUORO-4-IODOBENZONITRILE, is a light yellow crystalline compound that serves as a versatile building block in the synthesis of various pharmaceutical compounds. It is characterized by the presence of a fluorine atom at the 2nd position and an iodine atom at the 4th position of the benzonitrile molecule, which contributes to its unique chemical properties and reactivity.
Uses
Used in Pharmaceutical Industry:
2-FLUORO-4-IODOBENZONITRILE is used as a pharmaceutical intermediate for the synthesis of various therapeutic agents. Its unique structure allows it to be a key component in the development of novel drugs targeting specific biological pathways.
Used in the Synthesis of L. infantum trypanothione reductase (Li-TryR) Inhibitors:
2-FLUORO-4-IODOBENZONITRILE is used as a building block for the development of inhibitors targeting L. infantum trypanothione reductase (Li-TryR), an enzyme involved in the survival and replication of Leishmania parasites. These inhibitors can potentially be used in the treatment of leishmaniasis, a disease caused by these parasites.
Used in the Synthesis of Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists:
2-FLUORO-4-IODOBENZONITRILE is also utilized in the synthesis of antagonists for the transient receptor potential ankyrin 1 (TRPA1) channel, which is involved in various physiological processes, including pain sensation and inflammation. TRPA1 antagonists have potential applications in the treatment of chronic pain and inflammatory conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 137553-42-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,7,5,5 and 3 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 137553-42:
(8*1)+(7*3)+(6*7)+(5*5)+(4*5)+(3*3)+(2*4)+(1*2)=135
135 % 10 = 5
So 137553-42-5 is a valid CAS Registry Number.
137553-42-5Relevant articles and documents
A practical and general ipso iodination of arylboronic acids using N-iodomorpholinium iodide (NIMI) as a novel iodinating agent: mild and regioselective synthesis of aryliodides
Tale,Toradmal,Gopula
, p. 84910 - 84919 (2015/10/28)
A mild and efficient protocol for the ipso-iodination of aryl boronic acids using N-iodomorpholinium iodide (NIMI) generated in situ from morpholine and molecular iodine as a novel iodinating agent has been developed. The addition of a catalytic amount of copper iodide found to promote rate enhancement of the iodination reaction and dramatic increase in the yield depending upon the nature of the boronic acid was observed. The mechanistic study revealed that depending upon the nature of the substrate, either the classical ipso substitution or copper catalysed iododeborylation pathway overall dominates the present iodination reaction. The features such as mild reaction conditions, operational simplicity, high to excellent yields, excellent functional group compatibility and low catalyst loading make this method potentially useful in organic synthesis.
Further Studies on the Synthesis of Quinazolines from 2-Fluorobenzonitriles
Hynes, John B.,Tomazic, Alenka,Parrish, Christie A.,Fetzer, Oliver S.
, p. 1357 - 1364 (2007/10/02)
Recently, we reported that appropriately substituted 2-fluorobenzonitriles undergo cyclization with guanidine carbonate to afford 2,4-diaminoquinazolines usually in good to excellent yield.This paper describes the preparation of a variety of new 2,4-diaminoquinazolines substituted at positions five or seven.In addition, the reactions of selected 2-fluorobenzonitriles with formamidine acetate or acetamidine acetate were examined.The results obtained demonstrate that the analogous 4-amino- and 2-methyl-4-aminoquinazolines can be prepared by this approach but that yields are considerably lower than when guanidine carbonate is employed as the cyclization reagent.