137553-48-1 Usage
General Description
4-AMINO-5-FLUOROQUINAZOLINE is a chemical compound with the molecular formula C8H6N4F. It is a fluorinated quinazoline derivative, which is a type of heterocyclic compound. This chemical is used in the pharmaceutical industry as a building block for the synthesis of various pharmaceutical drugs. It has potential applications in the development of anti-cancer, anti-bacterial, and anti-inflammatory drugs. The fluorine substitution in the quinazoline structure can lead to improved drug-like properties, such as increased metabolic stability and enhanced binding affinity to target proteins. Additionally, 4-AMINO-5-FLUOROQUINAZOLINE may also have potential uses in other industries, such as in the development of agrochemicals or materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 137553-48-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,7,5,5 and 3 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 137553-48:
(8*1)+(7*3)+(6*7)+(5*5)+(4*5)+(3*3)+(2*4)+(1*8)=141
141 % 10 = 1
So 137553-48-1 is a valid CAS Registry Number.
InChI:InChI=1/C8H6FN3/c9-5-2-1-3-6-7(5)8(10)12-4-11-6/h1-4H,(H2,10,11,12)
137553-48-1Relevant articles and documents
Further Studies on the Synthesis of Quinazolines from 2-Fluorobenzonitriles
Hynes, John B.,Tomazic, Alenka,Parrish, Christie A.,Fetzer, Oliver S.
, p. 1357 - 1364 (2007/10/02)
Recently, we reported that appropriately substituted 2-fluorobenzonitriles undergo cyclization with guanidine carbonate to afford 2,4-diaminoquinazolines usually in good to excellent yield.This paper describes the preparation of a variety of new 2,4-diaminoquinazolines substituted at positions five or seven.In addition, the reactions of selected 2-fluorobenzonitriles with formamidine acetate or acetamidine acetate were examined.The results obtained demonstrate that the analogous 4-amino- and 2-methyl-4-aminoquinazolines can be prepared by this approach but that yields are considerably lower than when guanidine carbonate is employed as the cyclization reagent.