1375651-09-4 Usage
Description
1-[3-(4-acetyl-2-methoxyphenoxy)propyl]-4-(6-fluorobenzo[d]isoxazol-3-yl)piperidine N-oxide is a complex organic compound with a unique chemical structure. It is characterized by its molecular composition, which includes a piperidine N-oxide core, a 4-(6-fluorobenzo[d]isoxazol-3-yl) group, and a 3-(4-acetyl-2-methoxyphenoxy)propyl side chain. 1-[3-(4-acetyl-2-methoxyphenoxy)propyl]-4-(6-fluorobenzo[d]isoxazol-3-yl)piperidine N-oxide is synthesized as an impurity in the production of Iloperidone, a pharmaceutical agent with significant applications in the treatment of psychiatric disorders.
Uses
Used in Pharmaceutical Industry:
1-[3-(4-acetyl-2-methoxyphenoxy)propyl]-4-(6-fluorobenzo[d]isoxazol-3-yl)piperidine N-oxide is used as an impurity in the synthesis of Iloperidone (I267200) for its role as a combined dopamine (D2) and serotonin (5HT2) receptor antagonist. This application is significant in the development of antipsychotic medications, which are crucial for managing various psychiatric conditions.
As an impurity in the synthesis process, this compound may also be relevant in the study of the side effects or potential improvements in the efficacy of Iloperidone. Understanding the properties and interactions of this compound can contribute to the optimization of the synthesis process and the development of more effective antipsychotic drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 1375651-09-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,7,5,6,5 and 1 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1375651-09:
(9*1)+(8*3)+(7*7)+(6*5)+(5*6)+(4*5)+(3*1)+(2*0)+(1*9)=174
174 % 10 = 4
So 1375651-09-4 is a valid CAS Registry Number.
1375651-09-4Relevant articles and documents
Improved and efficient process for the production of highly pure iloperidone: A psychotropic agent
Solanki, Pavankumar V.,Uppelli, Sekhar Babu,Pandit, Bhushan S.,Mathad, Vijayavitthal T.
, p. 342 - 348 (2014/03/21)
The present work describes an improved and highly efficient process for the synthesis of iloperidone (1), an antipsychotic agent, which is free from potential impurities. The synthesis comprises N-alkylation of 1-(4-(3-chloropropoxy)-3-methoxyphenyl)ethanone (4) with 6-fluoro-3-piperidin-4- yl-1,2-benzisoxazole hydrochloride (5) in a mixture of water and heptane as solvent and sodium hydroxide as a base in the presence of tetrabutylammonium bromide as a phase transfer catalyst to yield iloperidone (1) with a yield of around 95% and a purity of 99.80% by HPLC. The present work also describes the optimization details performed to achieve the process attributes responsible for high yield and purity.
