1375958-75-0 Usage
Description
(1,4-diazabicyclo[2.2.2]octan-1-ium-1-ylsulfonyl)(tert-butoxycarbonyl)amide is a complex organic compound with a unique chemical structure. It is characterized by its diazabicyclo ring system and sulfonyl group, which contribute to its reactivity and potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
(1,4-diazabicyclo[2.2.2]octan-1-ium-1-ylsulfonyl)(tert-butoxycarbonyl)amide is used as a reagent for the preparation of MLN4924, a potent tumor inhibitor. MLN4924 targets the NEDD8-activating enzyme, which plays a crucial role in the regulation of the cell cycle and apoptosis. By inhibiting this enzyme, MLN4924 can disrupt the cell cycle and induce apoptosis in cancer cells, making it a promising candidate for cancer treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 1375958-75-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,7,5,9,5 and 8 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1375958-75:
(9*1)+(8*3)+(7*7)+(6*5)+(5*9)+(4*5)+(3*8)+(2*7)+(1*5)=220
220 % 10 = 0
So 1375958-75-0 is a valid CAS Registry Number.
1375958-75-0Relevant articles and documents
N-(tert -butoxycarbonyl)- N -[(triethylenediammonium)sulfonyl]azanide: A convenient sulfamoylation reagent for alcohols
Armitage, Ian,Berne, Alexander M.,Elliott, Eric L.,Fu, Mingkun,Hicks, Frederick,McCubbin, Quentin,Zhu, Lei
supporting information; experimental part, p. 2626 - 2629 (2012/07/28)
A convenient and efficient procedure is described for the sulfamoylation of alcohols using N-(tert-butoxycarbonyl)-N-[(triethylenediammonium)sulfonyl] azanide (1). The ambient temperature stable reagent 1 reacts with phenols as well as primary and secondary alcohols to give high to modest yields. The relative reaction rate of substrates was determined (primary > phenol > secondary ? tertiary). The reagent's utility as a selective sulfamoylation reagent with polyols is also demonstrated.