1376615-91-6 Usage
Description
8-cyclopentyl-6-(1-hydroxyethyl)-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one, also known as Palbociclib 1-?Hydroxyethyl, is a compound derived from Palbociclib (PD-0332991), an experimental drug developed by Pfizer for the treatment of breast cancer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6, which play a crucial role in cell cycle regulation and are often overactive in cancer cells. 8-cyclopentyl-6-(1-hydroxyethyl)-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one is an impurity of Palbociclib and has potential applications in the pharmaceutical industry due to its structural similarity and possible biological activity.
Uses
Used in Pharmaceutical Industry:
8-cyclopentyl-6-(1-hydroxyethyl)-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one is used as an impurity in the development and production of Palbociclib, a drug for the treatment of breast cancer. Its presence may affect the efficacy, safety, and quality control of the final drug product, making it essential to monitor and control its levels during the manufacturing process.
Additionally, due to its structural similarity to Palbociclib, this compound may have potential applications as a research tool or a starting material for the development of new drugs targeting CDK4 and CDK6 or other related pathways in cancer treatment.
Used in Research and Development:
8-cyclopentyl-6-(1-hydroxyethyl)-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one can be used as a research compound to study the structure-activity relationship of CDK4/6 inhibitors and their potential applications in cancer therapy. This may lead to the discovery of new drugs with improved efficacy, safety, or selectivity.
Used in Quality Control and Analytical Methods:
8-cyclopentyl-6-(1-hydroxyethyl)-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one can be employed as a reference compound in the development and validation of analytical methods for the quantification of impurities in Palbociclib. This is crucial for ensuring the quality, safety, and efficacy of the drug in clinical settings.
Check Digit Verification of cas no
The CAS Registry Mumber 1376615-91-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,7,6,6,1 and 5 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1376615-91:
(9*1)+(8*3)+(7*7)+(6*6)+(5*6)+(4*1)+(3*5)+(2*9)+(1*1)=186
186 % 10 = 6
So 1376615-91-6 is a valid CAS Registry Number.
1376615-91-6Relevant articles and documents
DRUG DERIVATIVES
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Paragraph 0406; 0407, (2013/09/12)
The present invention relates to derivatives of known active pharmaceutical compounds. These derivatives are differentiated from the parent active compound by virtue of being redox derivatives of the active compound. This means that one or more of the functional groups in the active compound has been converted to another group in one or more reactions which may be considered to represent a change of oxidation state. We refer to these compounds generally as redox derivatives. The derivatives of the invention may be related to the original parent active pharmaceutical compound by only a single step transformation, or may be related via several synthetic steps including one or more changes of oxidation state. In certain cases, the functional group obtained after two or more transformations may be in the same oxidation state as the parent active compound (and we include these compounds in our definition of redox derivatives). In other cases, the oxidation state of the derivative of the invention may be regarded as being different from that of the parent compound. In many cases, the compounds of the invention have inherent therapeutic activity on their own account. In some cases, this activity relative to the same target or targets of the parent compound is as good as or better than the activity which the parent compound has against the target or targets.
