1376632-32-4

Basic information

• Product Name: tert-butyl 1-benzyl-4'-hydroxy-2-oxo-4',5'-dihydro-2'H-spiro[indoline-3,3'-thiophene]-2'-carboxylate
• Synonyms: tert-butyl 1-benzyl-4'-hydroxy-2-oxo-4',5'-dihydro-2'H-spiro[indoline-3,3'-thiophene]-2'-carboxylate
• CAS NO: 1376632-32-4
• Molecular Weight: 411.522
• Mol File: 1376632-32-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: tert-butyl 1-benzyl-4'-hydroxy-2-oxo-4',5'-dihydro-2'H-spiro[indoline-3,3'-thiophene]-2'-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 1-benzyl-4'-hydroxy-2-oxo-4',5'-dihydro-2'H-spiro[indoline-3,3'-thiophene]-2'-carboxylate(1376632-32-4)
• EPA Substance Registry System: tert-butyl 1-benzyl-4'-hydroxy-2-oxo-4',5'-dihydro-2'H-spiro[indoline-3,3'-thiophene]-2'-carboxylate(1376632-32-4)

Safety Data

• Hazardous Substances Data: 1376632-32-4(Hazardous Substances Data)

Upstream product

• 40018-26-6 1,4-dithiane-2,5-diol 
• 1353885-71-8 C₂₁H₂₁NO₃ 
• 1217-89-6 1-benzylisatin 
• 86302-43-4 (tert-Butoxycarbonylmethylene)triphenylphosphorane 
• 1376631-46-7 tert-butyl (2E)-(1-benzyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)acetate 

Relevant articles and documents

Asymmetric synthesis of spirocyclic oxindole-fused tetrahydrothiophenes via n,n-dioxide-nickel(ii) catalyzed domino reaction of 1,4-dithiane-2,5-diol with 3-alkenyloxindoles

A highly efficient chiral N,N-dioxide-nickel(II) complex system has been developed to catalyze the domino thia-Michael/aldol reaction of 1,4-dithiane-2,5-diol with 3-alkenyloxindoles.A series of the desired spirocyclic oxindole-fused tetrahydrothiophenes was obtained in good yields with excellent ee and dr (up to 97% yield, 98% ee, >19:1 dr).Besides, based on the X-ray crystal structure of the catalyst as well as the absolute configuration of the product, a catalytic model was proposed to explain the stereocontrol process.