137693-53-9Relevant articles and documents
Enantioselective preparation of (2R,3R)-(+)- and (2S,3S)-(-)-2,3-epoxy- 2-methylbutanoic acids and some derivatives
Torres-Valencia, J. Martin,Cerda-Garcia-Rojas, Carlos M.,Joseph-Nathan, Pedro
, p. 757 - 764 (2007/10/03)
(2R,3R)-(+)- and (2S,3S)-(-)-2,3-epoxy-2-methylbutanoic acids (epoxyangelic acids) were prepared from (Z)-2-methyl-2-butenoic acid using the Sharpless asymmetric epoxidation method in combination with the use of (- )- and (+)-menthol as chiral auxiliaries. Both substances, obtained in high enantiomeric excess, were characterized by spectroscopic and optical activity data. Their absolute configuration was determined by correlation with (R)- (+)-2-methyl-1,2-butanediol.