1377966-35-2Relevant articles and documents
Dibenzo[c,h][1,5]naphthyridinediones as topoisomerase i inhibitors: Design, synthesis, and biological evaluation
Kiselev, Evgeny,Empey, Nicholas,Agama, Keli,Pommier, Yves,Cushman, Mark
, p. 5167 - 5172 (2012)
Dibenzo[c,h][1,5]naphthyridinediones were prepared via a novel synthetic pathway. The compounds were designed as topoisomerase I (Top1) inhibitors based on the indenoisoquinoline series of drugs. The results of biological evaluation demonstrate that, unlike very closely related dibenzo[c,h][1,6] naphthyridinediones, dibenzo[c,h][1,5]naphthyridinediones retain the Top1 inhibitory activity of similarly substituted indenoisoquinolines.